Molecular and Cellular Biochemistry

, Volume 222, Issue 1, pp 159–171

Carcinogenic metals and NF‐κB activation

  • Fei Chen
  • Min Ding
  • Vince Castranova
  • Xianglin Shi
Article

DOI: 10.1023/A:1017962113235

Cite this article as:
Chen, F., Ding, M., Castranova, V. et al. Mol Cell Biochem (2001) 222: 159. doi:10.1023/A:1017962113235

Abstract

Epidemiological and animal studies suggest that several metals and metal-containing compounds are potent mutagens and carcinogens. These metals include chromium, arsenic, vanadium, and nickel. During the last two decades, chemical and cellular studies have contributed enormously to our understanding of the mechanisms of metal-induced pathophysiological processes. Although each of these metals is unique in its mechanism of action, some common signaling molecules, such as reactive oxygen species (ROS), may be shared by many of these carcinogenic metals. New techniques are now available to reveal the mechanisms of carcinogenesis in precise molecular terms. In this review, we focused our attentions on metal-induced signal transduction pathways leading to the activation of NF-κB, a transcription factor governing the expression of most early response genes involved in a number of human diseases.

NF‐κB IKK metals signal transduction ROS 

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Fei Chen
    • 1
  • Min Ding
    • 1
  • Vince Castranova
    • 1
  • Xianglin Shi
    • 1
  1. 1.Health Effects Laboratory DivisionNational Institute for Occupational Safety and HealthMorgantownUSA

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