Individual Sensitivity to Genotoxic Effects of Nickel and Antimutagenic Activity of Ascorbic Acid
- Cite this article as:
- Perminova, I.N., Sinel'shchikova, T.A., Alekhina, N.I. et al. Bulletin of Experimental Biology and Medicine (2001) 131: 367. doi:10.1023/A:1017912521543
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Cytotoxicity of nickel compounds was studied by stimulating the repair synthesis of DNA and counting lymphocyte micronuclei in workers of smelting shop of copper-nickel sulfide processing plant. Nickel content in the organism was evaluated by its concentrations in hair. Therapy with ascorbic acid (1 g/day for 1 month) led to a significant decrease in the number of micronuclei. The number of micronuclei before and after ascorbic acid treatment varied within a wide range in different individuals.