European Journal of Epidemiology

, Volume 17, Issue 2, pp 141–144

Age-specific seroepidemiology of hepatitis A, B, and E infections among children in Istanbul, Turkey

  • M. Sıdal
  • E. Ünüvar
  • F. Oğuz
  • C. Cihan
  • D. Önel
  • S. Badur
Article

DOI: 10.1023/A:1017524630372

Cite this article as:
Sıdal, M., Ünüvar, E., Oğuz, F. et al. Eur J Epidemiol (2001) 17: 141. doi:10.1023/A:1017524630372

Abstract

This study was performed for evaluation of seroprevalence of hepatitis A, B, and E among children in Istanbul, Turkey. The study group included 909 children who were 6 months–15 years of age. The children were separated to three age groups: Group 1 (6 months–4.9 years; n = 321), Group 2 (5.0–9.9 years; n = 318), and Group 3 (10.0–15.0 years; n = 270). Group 1 was divided to two subgroups for evaluation of the maternal antibody sera (6 months–2 years and over 2 years). Serum IgG anti-HAV, anti-HBc, and anti-HEV were tested by commercial ELISA kits. The data were studied by multivariant analysis. In all subjects, seroprevalence of hepatitis A, B, and E were determined as 29, 15.9, and 2.1% respectively. The prevalence of hepatitis A increased with age (p < 0.05; Group 1 15.1% and Group 3 49.6%). Anti-HBc IgG level did not significantly change with age (Group 1 18.6% and Group 3 15.4%; p > 0.05). The seroprevalence of hepatitis E virus infection was higher in Group 1 (3.7%) than Group 3 (0.3%; p < 0.05). In Group 1 first subgroup, between 6 month and 2 year, antibody levels were 12.2, 17.3, and 4.8% respectively, for anti-HAV IgG, anti-HBc IgG and anti-HEV IgG. Hepatitis A and B infection is a community health problem, but hepatitis E infection is low in children in Istanbul, Turkey. The high positive rate in Group 1 for IgG anti-HEV may be due to maternal antibodies.

ChildHepatitis AHepatitis BHepatitis E

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • M. Sıdal
    • 1
  • E. Ünüvar
    • 1
  • F. Oğuz
    • 1
  • C. Cihan
    • 1
  • D. Önel
    • 2
  • S. Badur
    • 2
  1. 1.Department of PediatricsInstitute of Child HealthIstanbulTurkey
  2. 2.Department of Microbiology, Istanbul Medical FacultyUniversity of IstanbulIstanbulTurkey