Age-specific seroepidemiology of hepatitis A, B, and E infections among children in Istanbul, Turkey
Cite this article as: Sıdal, M., Ünüvar, E., Oğuz, F. et al. Eur J Epidemiol (2001) 17: 141. doi:10.1023/A:1017524630372 Abstract
This study was performed for evaluation of seroprevalence of hepatitis A, B, and E among children in Istanbul, Turkey. The study group included 909 children who were 6 months–15 years of age. The children were separated to three age groups: Group 1 (6 months–4.9 years; n = 321), Group 2 (5.0–9.9 years; n = 318), and Group 3 (10.0–15.0 years; n = 270). Group 1 was divided to two subgroups for evaluation of the maternal antibody sera (6 months–2 years and over 2 years). Serum IgG anti-HAV, anti-HBc, and anti-HEV were tested by commercial ELISA kits. The data were studied by multivariant analysis. In all subjects, seroprevalence of hepatitis A, B, and E were determined as 29, 15.9, and 2.1% respectively. The prevalence of hepatitis A increased with age (
p < 0.05; Group 1 15.1% and Group 3 49.6%). Anti-HBc IgG level did not significantly change with age (Group 1 18.6% and Group 3 15.4%; p > 0.05). The seroprevalence of hepatitis E virus infection was higher in Group 1 (3.7%) than Group 3 (0.3%; p < 0.05). In Group 1 first subgroup, between 6 month and 2 year, antibody levels were 12.2, 17.3, and 4.8% respectively, for anti-HAV IgG, anti-HBc IgG and anti-HEV IgG. Hepatitis A and B infection is a community health problem, but hepatitis E infection is low in children in Istanbul, Turkey. The high positive rate in Group 1 for IgG anti-HEV may be due to maternal antibodies. Child Hepatitis A Hepatitis B Hepatitis E References
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