Chromosome Research

, Volume 9, Issue 3, pp 223–233

Identification and characterization of satellite III subfamilies to the acrocentric chromosomes

  • Authors
  • R. Bandyopadhyay
  • C. McQuillan
  • S. L. Page
  • K. H. A. Choo
  • L. G. Shaffer
Article

DOI: 10.1023/A:1016648404388

Cite this article as:
Bandyopadhyay, R., McQuillan, C., Page, S.L. et al. Chromosome Res (2001) 9: 223. doi:10.1023/A:1016648404388

Abstract

The centromeres and the short arms of the five pairs of acrocentric chromosomes in humans are composed of tandemly ordered repetitive DNA. Previous studies have suggested that the exchanges between acrocentric chromosomes have resulted in concerted evolution of different DNA sequences in their short arms. The acrocentric chromosomes are clinically relevant since they are involved in Robertsonian translocation formation and non-disjunction resulting in aneuploidy. Here we have identified seven new satellite III repetitive DNA subfamilies, determined their nucleotide sequences and established their chromosomal distributions on the short arms of the acrocentric chromosomes. Knowledge of these related sequences may help to elucidate the molecular basis of Robertsonian translocation formation.

acrocentric chromosomechromosome evolutionfluorescence in-situ hybridizationrepetitive DNAsatellite DNARobertsonian translocations

Copyright information

© Kluwer Academic Publishers 2001