Article

Breast Cancer Research and Treatment

, Volume 74, Issue 3, pp 213-220

First online:

Prognostic Value of Thermographical Findings in Patients with Primary Breast Cancer

  • Shozo OhsumiAffiliated withDepartment of Surgery, National Shikoku Cancer Center
  • , Shigemitsu TakashimaAffiliated withDepartment of Surgery, National Shikoku Cancer Center
  • , Kenjiro AogiAffiliated withDepartment of Surgery, National Shikoku Cancer Center
  • , Hisashi UsukiAffiliated with1st Department of Surgery, Kagawa Medical University

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Abstract

Thermography is a technique to measure the body surface temperature and is used in medical applications. We evaluated its prognostic value in 340 female patients with unilateral invasive breast cancer without distant metastases. The difference of mean temperatures of the tumor area and corresponding area of the contralateral breast was defined as ΔT. The patients with hot tumors (Δ T ≥ 0.9°C) had significantly worse disease free and specific survival than those with cold tumors (Δ T < 0.9°C) (p = 0.0003 and p < 0.0001, respectively). ΔT was significantly correlated with tumor size, histological nodal status and nuclear grade, positively. But ΔT did not have any relation with estrogen receptor status. Multivariate analyses including those conventional prognostic factors showed that ΔT was a marginally significant prognostic factor for disease-free survival (hazard ratio (HR) = 1.62; 95% confidence interval (CI) = 0.99–2.66, p = 0.0557) and an independent significant prognostic one for disease specific survival (HR = 1.95; 95% CI = 1.09–3.49, p = 0.0251). However, ΔT did not have prognostic impact on the node negative patients. ΔT might be a useful prognostic factor in node positive breast cancer, especially in patients who plan to be treated with preoperative systemic therapy.

breast cancer prognostic factor thermography