Analgesic and Immunomodulatory Effects of Codeine and Codeine 6-glucuronide
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Purpose. The antinociceptive and immunosuppressive effects of codeine and codeine 6-glucuronide were determined in rats after intra-cerebroventricular administration.
Methods. Codeine 6-glucuronide was synthesized using a modification of the Koenigs-Knorr reaction. A lipophilic intermediate formed during synthesis, methyl [codein-6-yl-2,3,4-tri-O-acetyl-β-D-glucopyranosid] uronate, was also tested. Morphine was used as a positive control to compare antinociceptive potencies of these compounds.
Results. All compounds tested produced significant analgesic responses, as assessed by the tail flick model. Additionally, codeine 6-glucuronide showed significantly less immunosuppressive effects than codeine in vitro.
Conclusions. We conclude that codeine 6-glucuronide and related compounds may have clinical benefit in the treatment of pain in immune compromised patients.
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- Analgesic and Immunomodulatory Effects of Codeine and Codeine 6-glucuronide
Volume 13, Issue 2 , pp 296-300
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- 1. Department of Pharmaceutics, University of Florida, Gainesville, Florida, 32610
- 2. Department of Pharmacodynamics, University of Florida, Gainesville, Florida, 32610
- 3. Department of Pharmacy Practice, University of Florida, Gainesville, Florida, 32610
- 4. Department of Medicinal Chemistry, University of Florida, Gainesville, Florida, 32610