Molecular and Cellular Biochemistry

, Volume 234, Issue 1, pp 277–282

Arsenic carcinogenicity: Relevance of c-Src activation

  • Petia P. Simeonova
  • Michael I. Luster

DOI: 10.1023/A:1015971118012

Cite this article as:
Simeonova, P.P. & Luster, M.I. Mol Cell Biochem (2002) 234: 277. doi:10.1023/A:1015971118012


Environmental and occupational exposure to arsenic is associated with increased risk of skin, urinary bladder and respiratory tract cancers. Increasing evidence indicates that arsenic acts at the level of tumor promotion by modulating the signaling pathways responsible for cell growth. One of this pathways might include c-Src dependent EGFR and MAPK activation.

gene expressionreactive oxygen speciesskin cancerbladder cancer

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Petia P. Simeonova
    • 1
  • Michael I. Luster
    • 1
  1. 1.Toxicology and Molecular Biology Branch, Health Effects Laboratory DivisionNational Institute for Occupational Safety and HealthMorgantowUSA