Arsenic carcinogenicity: Relevance of c-Src activation
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- Simeonova, P.P. & Luster, M.I. Mol Cell Biochem (2002) 234: 277. doi:10.1023/A:1015971118012
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Environmental and occupational exposure to arsenic is associated with increased risk of skin, urinary bladder and respiratory tract cancers. Increasing evidence indicates that arsenic acts at the level of tumor promotion by modulating the signaling pathways responsible for cell growth. One of this pathways might include c-Src dependent EGFR and MAPK activation.