Pharmaceutical Research

, Volume 6, Issue 9, pp 743-747

First online:

Ion Pair Transport Across Membranes

  • Reinhard NeubertAffiliated withSektion Pharmazie der, Martin-Luther-Universität

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The present review discusses drugs and counter ions suitable for ion pair transport (IPT). Ion pairing is shown to effectively increase the lipophilicity and transport rate of polar drugs across lipid membranes. The proposed mechanisms of IPT are discussed in detail. A marked change in drug properties upon ion pair formation is necessary to improve the bioavailability of hydrophilic ionizable drugs.

ion pair transport (IPT) mechanism of IPT hydrophilic drugs counter ions effects on pharmacokinetics