Pharmaceutical Research

, Volume 8, Issue 11, pp 1408–1412

Viscometric Study of Polyacrylic Acid Systems as Mucoadhesive Sustained-Release Gels

  • James S. Chu
  • Ramachandran Chandrasekharan
  • Gordon L. Amidon
  • Norman D. Weiner
  • Arthur H. Goldberg
Article

DOI: 10.1023/A:1015805307999

Cite this article as:
Chu, J.S., Chandrasekharan, R., Amidon, G.L. et al. Pharm Res (1991) 8: 1408. doi:10.1023/A:1015805307999

Abstract

This report describes a novel nonaqueous polymeric formulation that exhibits low-viscosity fluid behavior for ease of spraying with conventional nebulizer, which when sprayed into the nasal cavity, transforms to a high-viscosity gel for efficient retention and drug absorption. The transformation occurs because of the rheological changes induced by a change in the solvent composition of the polymeric formulation in the moist nasal cavity. Such a rheological change would then facilitate enhanced residence time of the drug at the site of administration in order to avoid drainage losses. This study reports the results of the effects of a variety of factors such as solvent composition and polymer concentration on the rheological properties of a polyacrylic acid polymer. An attempt to correlate viscosity enhancement effects with enhanced and sustained-release behavior of propranolol, a drug that undergoes extensive first-pass effects, from such formulations via nasal administration in beagle dogs is also described.

pharmaceutical gel formulation Carbopol gel viscosity propranolol solvent effects on polymer gel rheology 

Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • James S. Chu
    • 1
  • Ramachandran Chandrasekharan
    • 1
  • Gordon L. Amidon
    • 1
  • Norman D. Weiner
    • 1
  • Arthur H. Goldberg
    • 3
  1. 1.College of PharmacyUniversity of MichiganAnn Arbor
  2. 2.Institute of Pharmaceutical Sciences, Syntex ResearchPalo Alto
  3. 3.Rubgy Darby Group Companies, Inc.Rockville Centre

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