Cancer Causes & Control

, Volume 13, Issue 5, pp 417–426

A prospective study of medical conditions, anthropometry, physical activity, and pancreatic cancer in male smokers (Finland)

  • Rachael Z. Stolzenberg-Solomon
  • Pirjo Pietinen
  • Philip R. Taylor
  • Jarmo Virtamo
  • Demetrius Albanes
Article

DOI: 10.1023/A:1015729615148

Cite this article as:
Stolzenberg-Solomon, R.Z., Pietinen, P., Taylor, P.R. et al. Cancer Causes Control (2002) 13: 417. doi:10.1023/A:1015729615148

Abstract

Objective: To examine the association between several medical conditions, anthropometric measurements, occupational and leisure physical activity, and pancreatic cancer in a cohort of male Finnish smokers. Methods: We performed a cohort analysis of the 172 subjects who developed pancreatic cancer between 1985 and 1997 (median 10.2 years follow-up) among the 29,048 male smokers, 50–69 years old, who had complete baseline data and participated in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Cox proportional hazards models were used to estimate multivariable adjusted hazard ratios (HR) and 95% confidence intervals (CI). Results: We observed positive associations between pancreatic cancer risk and self-reported history of diabetes mellitus (HR = 2.02, 95% CI 1.17–3.50) and bronchial asthma (HR = 2.16, 95% CI 1.17–3.98). Men having combined occupational and leisure activity greater than at sedentary levels had reduced risk for the cancer; for example those with moderate/heavy activity in both settings showed a HR of 0.42 (95% CI 0.22–0.83). There were no significant associations with other self-reported illnesses, total or HDL (high-density lipoprotein) cholesterol, height, weight, or body mass index. Conclusions: Our data suggest that diabetes mellitus and bronchial asthma predict the subsequent risk of developing pancreatic cancer in male smokers, and that greater physical activity may reduce the risk.

anthropometry medical conditions metabolic syndrome pancreatic cancer physical activity smokers 

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Rachael Z. Stolzenberg-Solomon
    • 1
    • 2
    • 3
    • 4
  • Pirjo Pietinen
    • 5
  • Philip R. Taylor
    • 6
  • Jarmo Virtamo
    • 5
  • Demetrius Albanes
    • 1
  1. 1.Nutritional Epidemiology Branch, Division of Cancer Epidemiology and GeneticsNational Cancer InstituteRockvilleUSA
  2. 2.Division of Cancer PreventionNational Cancer InstituteRockvilleUSA
  3. 3.Nutritional Epidemiology Branch, Division of Cancer Epidemiology and GeneticsNational Cancer InstituteBethesda
  4. 4.RockvilleUSA
  5. 5.National Public Health InstituteHelsinkiFinland
  6. 6.Cancer Prevention Studies Branch, Center for Clinical ResearchNational Cancer InstituteRockvilleUSA

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