Treatment and quality of life in patients with chronic obstructive pulmonary disease
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Treatments administered to patients with chronic obstructive pulmonary disease (COPD), especially when used in multiple combinations, are not free of interactions and side effects that can potentially impair health-related quality of life (HRQL). We studied HRQL and its relationship with treatment in a group of 441 patients with stage II or III COPD (age: 66.6 (SD: 8.3) years; FEV1: 32.4% (SD: 8.1%)) using the St George's Respiratory Questionnaire (SGRQ) and the 12-item short form (SF-12) Health Survey. The most prescribed drugs were ipratropium bromide (87.5%), inhaled corticosteroids (69.4%) and short-acting β-2 agonists (64.9%). Patients with stage III of the disease were receiving more drugs, particularly short-acting β-2 agonists (p = 0.002) and inhaled corticosteroids (p = 0.031). The use of theophyllines was associated with a worse total SGRQ score (β = 4.49; p < 0.001), although this negative association decreased with advanced age. A trend towards worse SGRQ scores was observed with the use of high doses of long-acting β-2 agonists (β = 3.22; p = 0.072). Patients receiving three drugs or more presented worse total SGRQ scores than patients receiving fewer drugs (β = 6.1, p < 0.001; and β = 7.64, p < 0.001, respectively). These findings suggest that the use of multiple drugs in the treatment of patients with COPD is associated with worse total SGRQ scores. The effect of drugs, their dosages and associations with other drugs on HRQL merit further research.
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- Treatment and quality of life in patients with chronic obstructive pulmonary disease
Quality of Life Research
Volume 11, Issue 4 , pp 329-338
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers
- Additional Links
- Chronic obstructive pulmonary disease
- Health-related quality of life
- St George's Respiratory Questionnaire
- SF-12 Health Survey
- Industry Sectors
- Author Affiliations
- 1. Servei de Pneumologia, Hospital General Vall d'Hebron, Barcelona, Spain
- 2. Servicio de Neumología, Hospital Clínico San Carlos, Madrid, Spain
- 3. Health Services Research Unit, Institut Municipal d'Investigació Mèdica, Barcelona, Spain
- 4. Servicio de Neumología, Hospital San Pedro de Alcántara, Cáceres, Spain
- 5. Servicio de Neumología, Hospital Juan Canalejo, La Coruña, Spain
- 6. Unidad de Patología Respiratoria, Hospital de Cruces, Baracaldo (Vizcaya), Spain
- 7. Unitat de Pneumologia, Hospital General de Catalunya, Barcelona, Spain
- 8. R&D Department QF Bayer, Barcelona, Spain