Quality of Life Research

, Volume 11, Issue 4, pp 329–338

Treatment and quality of life in patients with chronic obstructive pulmonary disease

  • M. Miravitlles
  • J.L. Alvarez-Sala
  • R. Lamarca
  • M. Ferrer
  • F. Masa
  • H. Verea
  • R. Zalacain
  • C. Murio
  • F. Ros
  • R. Vidal
Article

DOI: 10.1023/A:1015520110663

Cite this article as:
Miravitlles, M., Alvarez-Sala, J., Lamarca, R. et al. Qual Life Res (2002) 11: 329. doi:10.1023/A:1015520110663

Abstract

Treatments administered to patients with chronic obstructive pulmonary disease (COPD), especially when used in multiple combinations, are not free of interactions and side effects that can potentially impair health-related quality of life (HRQL). We studied HRQL and its relationship with treatment in a group of 441 patients with stage II or III COPD (age: 66.6 (SD: 8.3) years; FEV1: 32.4% (SD: 8.1%)) using the St George's Respiratory Questionnaire (SGRQ) and the 12-item short form (SF-12) Health Survey. The most prescribed drugs were ipratropium bromide (87.5%), inhaled corticosteroids (69.4%) and short-acting β-2 agonists (64.9%). Patients with stage III of the disease were receiving more drugs, particularly short-acting β-2 agonists (p = 0.002) and inhaled corticosteroids (p = 0.031). The use of theophyllines was associated with a worse total SGRQ score (β = 4.49; p < 0.001), although this negative association decreased with advanced age. A trend towards worse SGRQ scores was observed with the use of high doses of long-acting β-2 agonists (β = 3.22; p = 0.072). Patients receiving three drugs or more presented worse total SGRQ scores than patients receiving fewer drugs (β = 6.1, p < 0.001; and β = 7.64, p < 0.001, respectively). These findings suggest that the use of multiple drugs in the treatment of patients with COPD is associated with worse total SGRQ scores. The effect of drugs, their dosages and associations with other drugs on HRQL merit further research.

Chronic obstructive pulmonary diseaseHealth-related quality of lifeSt George's Respiratory QuestionnaireSF-12 Health SurveyTreatment

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • M. Miravitlles
    • 1
  • J.L. Alvarez-Sala
    • 2
  • R. Lamarca
    • 3
  • M. Ferrer
    • 3
  • F. Masa
    • 4
  • H. Verea
    • 5
  • R. Zalacain
    • 6
  • C. Murio
    • 7
  • F. Ros
    • 8
  • R. Vidal
    • 1
  1. 1.Servei de PneumologiaHospital General Vall d'HebronBarcelonaSpain
  2. 2.Servicio de NeumologíaHospital Clínico San CarlosMadridSpain
  3. 3.Health Services Research UnitInstitut Municipal d'Investigació MèdicaBarcelonaSpain
  4. 4.Servicio de NeumologíaHospital San Pedro de AlcántaraCáceresSpain
  5. 5.Servicio de NeumologíaHospital Juan CanalejoLa CoruñaSpain
  6. 6.Unidad de Patología RespiratoriaHospital de CrucesBaracaldo (Vizcaya)Spain
  7. 7.Unitat de PneumologiaHospital General de CatalunyaBarcelonaSpain
  8. 8.R&D Department QF BayerBarcelonaSpain