Do NSAIDs Affect the Progression of Osteoarthritis?
10.1023/A:1015504632021 Cite this article as: Ding, C. Inflammation (2002) 26: 139. doi:10.1023/A:1015504632021 Abstract
NSAIDs are widely used to alleviate the symptoms of OA. It remains controversial as to what effects these agents have on the progression of OA.
In vitro studies showed several types of NSAIDs (e.g., sodium salicylate, indomethacin) inhibited the synthesis of cartilage matrix component, but some types of NSAIDs (e.g., aceclofenac, meloxicam, nimesulide) increased the matrix component synthesis and protected the chondrocytes against apoptosis, while others (e.g., piroxicam) had no effects. Studies in animal models verified that NSAIDs had favourable or detrimental action on OA progression, even the same NSAID (e.g., naproxen, tiaprofenic acid) had reverse effects on articular cartilage in different studies. Preliminary clinical trials revealed some NSAIDs such as indomethacin had a negative influence on joint structure, other NSAIDs such as diclofenac and naproxen had no acceleration of radiographic damage to OA within 2-years of treatment. So far, there are no convincing data to show the widely used NSAIDs and recommended selective COX-2 inhibitor have favourable effects on cartilage. Therefore, it is necessary and valuable to clarify the effects of these NSAIDs on cartilage in patients with OA using validated non-invasive methods such as MRI. NSAIDs Osteoarthritis Progression cartilage REFERENCES
Felson, D. T. and Y. Zhang. 1998. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention.
Goldring, M. B. 2000. The role of the chondrocyte in osteoarthritis.
Hungin, A. P. S. and D. W. F. Kean. 2001. Nonsteroidal antiin-flammatory drugs: overused or underused in osteoarthritis?
Blot, L., A. Marcelis, J. P. Devogelaer, and D. P. Manicourt. 2000.Effects of diclofenac, aceclofenac and meloxicam on metabolism of proteoglycans and hyaluronan in osteoarthritis human cartilage.
Br. J. Pharmacol.
Mukherjee, P., C. Rachita, P. S. Aisen, and G. M. Pasinetti. 2001.Non-steroidal anti-inflammatory drugs protect against chondrocyte apoptotic death.
Clin. Exp. Rheumatol.
19(1 Suppl 22)
Notoya K, D. V. Jovanovic, and P. Reboul
2000. The induction of cell death in human osteoarthritis chondrocytes by nitric oxide is related to the production of prostaglandin E2 via the induction of cyclooxygenase-2.
Dingle, J. 1996. Effects of NSAIDs on human articular glycosaminoglycan synthesis.
Eur. J. Rheu. Inflam.
Henrotin, Y. and T. Y. Reginster. 1999.
differences among nonsteroidal antiinflammatory drugs in their activities related to osteoarthritis pathophysiology.
Serni U., A. Mannoni, and M. Benucci. 1999. Is there preliminary
an influence of nonsteroidal antiinflammatory drug treatment on osteoarthritis progression? Part II-evidence from animal models.
Ratcliffe, A., M. P. Rosenwasser, and F. Mahmud
effects of naproxen on canine experimental osteoarthritic articular cartilage: composition, metalloproteinase activities and metabolism.
Agents Actions Suppl.
Pelletier J. P., D. Lajeunesse, and D. V. Jovanovic
2000.Carprofen simultaneously reduces progression of morphological changes in cartilage and subchondral bone in experimental dog osteoarthritis.
Fernandes J. C., J. P. Caron, and J. Martel-Pelletier
1997.Effects of tenidap on the progression of osteoarthritic lesions in a canine experimental model. Suppression of metalloprotease and interleukin-1 activity.
Chan C. C., S. Boyce, and C. Brideau
1999. Rofecoxib: A potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.
J Pharmacol. Exp. Ther.
Gencosmanoglu, B. E., M. Eryavuz, and S. Dervisoglu. 2001.Effects of some nonsteroidal anti-inflammatory drugs on articular cartilage of rats in an experimental model of osteoarthritis.
Res.Exp. Med. 200(3):
Rashad S., P. Revell, and A. Hemingway
1989. Effect of non steroidal antiinflammatory drugs on the course of osteoarthritis.
Huakinsson E. C., H. Berry, and P. Gishen
on behalf of the LINK study group. 1995. Effects of antiinflammatory drugs on the progression of osteoarthritis of the knee.
Dieppe P., J. Cushnaghan, and M. K. Jasani
1993. A twoyear, placebo-controlled trial of non-steroidal nonantiflammatory therapy in osteoarthritis of the knee joint.
Br. J. Rheumatol.
Williams H. J., J. R. Ward, and M. J. Egger
1993. Comparison of naproxen and acetaminophen in a two-year study of the treatment of osteoarthritis of the knees.
Sharma S., S. Rastogi, V. Gupta, D. Rohtagi, and P. Gulati. 1999.Comparative efficacy and safety of nimesulide versus piroxicam in osteoarthritis with special reference to chondroprotection.
Recommendations for the registration of drugs used in the treatment of osteoarthritis. 1996.
Ann. Rheu. Dis.
Pelletier, J. P. 1999. The influence of tissue cross-talking on OA progression: Role of nonsteroidal antiinflammatory drugs.
Mcmanus P., J. G. Pimrose, and D. A. Henry
1996. Pattern of non-steroidal antiinflammatory drug in Australia 1990–1994.
Lipsky, P. E. 2001. Recommendation for the clinical use of cyclooxygenase-2-specificied inhibitors.
Am. J. Med.
Jones G., M. Glisson, K. Hynes, and F. Cicuttini. 2000. Sex and site differences in cartilage development: a possible explanation for variations in knee osteoarthritis in later life.
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