The Human ASCL2 Gene Escaping Genomic Imprinting and Its Expression Pattern

  • Toshinobu Miyamoto
  • Shiga Hasuike
  • Yoshihiro Jinno
  • Hidenobu Soejima
  • Kankatsu Yun
  • Kiyonori Miura
  • Mutsuo Ishikawa
  • Norio Niikawa
Article

DOI: 10.1023/A:1015362903486

Cite this article as:
Miyamoto, T., Hasuike, S., Jinno, Y. et al. J Assist Reprod Genet (2002) 19: 240. doi:10.1023/A:1015362903486

Abstract

The mouse achaete-scute homolog-2 gene (Ascl2 or Mash2) encodes a transcription factor playing a role in the development of the trophoblast. The Ascl2 is an imprinted gene with maternal expression and assigned to an imprinting gene cluster region (ICR) at a distal region of mouse chromosome 7. We previously isolated a phage clone carrying the human homolog, ASCL2, and mapped it to human chromosome 11p15.5, a human ICR. In the present study, we demonstrate the expression patterns of the human ASCL2 in the fetus at a stage between first and second trimesters and in the placental tissues. In addition, it has been shown that the human ASCL2 gene escapes genomic imprinting.

ASCL2imprintingexpressionplacenta

Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • Toshinobu Miyamoto
    • 1
    • 2
  • Shiga Hasuike
    • 1
  • Yoshihiro Jinno
    • 1
  • Hidenobu Soejima
    • 1
    • 3
  • Kankatsu Yun
    • 4
  • Kiyonori Miura
    • 1
    • 5
  • Mutsuo Ishikawa
    • 2
  • Norio Niikawa
    • 1
  1. 1.Department of Human Genetics, School of MedicineNagasaki UniversityNagasakiJapan
  2. 2.Department of Obstetrics and GynecologyAsahikawa Medical CollegeAsahikawaJapan
  3. 3.Department of BiochemistrySaga Medical SchoolNabeshima, SagaJapan
  4. 4.Department of PathologyDunedin School of Medicine, University of OtagoDunedinNew Zealand
  5. 5.Department of Obstetrics and Gynecology, School of MedicineNagasaki UniversityNagasakiJapan