Molecular Biology

, Volume 36, Issue 2, pp 196–201

Mobile Gene Cassettes and Integrons

  • N. P. Kovalevskaya

DOI: 10.1023/A:1015361704475

Cite this article as:
Kovalevskaya, N.P. Molecular Biology (2002) 36: 196. doi:10.1023/A:1015361704475


Integrons are unique natural systems for capturing and spreading the antibiotic resistance genes among Gram-negative bacteria. Gene transfer into small genomes and into plasmids is via site-specific recombination. Integrons act as receptors of antibiotic resistance cassettes. There are known more than 50 cassettes conferring resistance to β-lactams, aminoglycosides, trimethoprim, chloramphenicol, streptomycin, and other antibiotics. The structure of integrons and of gene cassettes are described and the mechanisms of capture, mobilization, and expression of cassettes considered.

integron site-specific recombination gene cassette insertion system antibiotic resistance 

Copyright information

© MAIK “Nauka/Interperiodica” 2002

Authors and Affiliations

  • N. P. Kovalevskaya
    • 1
  1. 1.Institute of Microbial Ecology and Genetics, Ural DivisionRussian Academy of SciencesPermRussia

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