Biometals

, Volume 15, Issue 2, pp 133–144

New synthetic catecholate-type siderophores with triamine backbone

  • Lothar Heinisch
  • Peter Gebhardt
  • Renate Heidersbach
  • Rolf Reissbrodt
  • Ute Möllmann
Article

DOI: 10.1023/A:1015293900133

Cite this article as:
Heinisch, L., Gebhardt, P., Heidersbach, R. et al. Biometals (2002) 15: 133. doi:10.1023/A:1015293900133
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Abstract

New analogues of triscatecholate siderophores based on linear or tripodal triamines with or without spacer groups or lipophilic and hydrophilic substituents were synthesized. The catecholate moieties were prepared in OH-forms, as acetylated compounds or masked as 8-methoxycarbonyloxy-2,4-dioxo-1,3-benzoxazine derivatives. Some of the new compounds were active as siderophores tested by growth promotion assays using various Gram-negative bacteria and mycobacteria under iron limitation and by CAS-assay. Structure-activity-correlations have been studied.

siderophore analogue triscatecholate triamine backbone synthesis Gram-negative bacteria mycobacteria growth promotion 

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Lothar Heinisch
    • 1
  • Peter Gebhardt
    • 1
  • Renate Heidersbach
    • 1
  • Rolf Reissbrodt
    • 2
  • Ute Möllmann
    • 1
  1. 1.Hans Knöll-Institut for Natural Products ResearchJenaGermany
  2. 2.Robert Koch-InstitutWernigerodeGermany