Digestive Diseases and Sciences

, Volume 47, Issue 4, pp 856–861

Melatonin Prevents Ethanol-Induced Gastric Mucosal Damage Possibly Due to Its Antioxidant Effect


  • Dilek Bilici
    • Department of PharmacologyAtatürk Üniversitesi Tip Fakültesi, Farmakoloji anabilim dali
  • Halis Süleyman
    • Department of Pharmacology, Medical SchoolAtatürk University
  • Z. Nur Banoğlu
    • Department of Pharmacology, Medical SchoolAtatürk University
  • Ahmet Kiziltunç
    • Department of Biochemistry, Medical SchoolAtatürk University
  • Bahattin Avci
    • Department of Biochemistry, Medical SchoolAtatürk University
  • Akif Çiftçioğlu
    • Department of Pathology, Medical SchoolAtatürk University
  • Sefa Bilici
    • Numune Hospital

DOI: 10.1023/A:1014764705864

Cite this article as:
Bilici, D., Süleyman, H., Banoğlu, Z.N. et al. Dig Dis Sci (2002) 47: 856. doi:10.1023/A:1014764705864


Oxygen radical release has been proposed as a pathogenic factor of the ethanol-induced acute gastric injury. Melatonin, a pineal hormone, is known to scavenge oxygen free radicals. We investigated whether parenteral administration of melatonin prevented ethanol-induced macroscopic damage, polymorphonuclear (PMN) leukocyte infiltration, depletion of total glutathione (tGSH) concentration, and glutathione reductase (GSSG-Rd) activity in the rat gastric mucosa. We compared the effects of melatonin with those of omeprazole. Ethanol-induced mucosal damage was evaluated using three different parameters: gastric total glutathione (tGSH) concentration and glutathione reductase (GSSG-Rd) activity, the number of PMN leukocytes, and macroscopic investigation. Gatric tGSH concentration and GSSG-Rd activity decreased and the number of PMNs increased after ethanol administration. It was found that pretreatment with melatonin increased both tGSH concentration and GSSG-Rd activity. Melatonin also reduced ethanol-induced PMN infiltration in the stomach. Ethanol administration damaged the entire gastric mucosa. Melatonin significantly decreased the extent of ethanol-induced macroscopic injury. In conclusion, these findings support the conclusion that the protection conferred by melatonin in gastric ulcer is presumably due to its antioxidant activity.

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Copyright information

© Plenum Publishing Corporation 2002