, Volume 153, Issue 3, pp 141–144

Serological differences in two Blastomyces dermatitidis isolates from different geographical regions of North America

  • R. C. Axtell
  • G. M. Scalarone

DOI: 10.1023/A:1014599115064

Cite this article as:
Axtell, R.C. & Scalarone, G.M. Mycopathologia (2002) 153: 141. doi:10.1023/A:1014599115064


Yeast phase lysate antigens were prepared from two isolates (T-58 and ERC-2) from different geographic locations, Tennessee and Wisconsin. These lysate were evaluated with respect to their ability to detect antibody in dogs infected with blastomycosis and rabbits immunized with the lysates by an enzyme linked immunosorbent assay (ELISA). Both the dog sera and rabbit sera assays demonstrated that there were serological differences in these two isolates, which implied that there was antigenic variance in geographical populations of B. dermatitidis. These results correlated with a previous molecular study that indicated that there are genetic differences in different geographical populations of the organism.

Blastomyces dermatitidisblastomycosisELISAgeographical differenceslysate antigensserology

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • R. C. Axtell
    • 1
  • G. M. Scalarone
    • 1
  1. 1.Department of Biological SciencesIdaho State UniversityPocatello, IdahoUSA