Cancer Causes & Control

, Volume 12, Issue 10, pp 959–964

Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis: a case–control study in Italy


  • Francesco Donato
    • Cattedra di IgieneUniversità di Brescia
  • Umberto Gelatti
  • Alessandro Tagger
    • Istituto di VirologiaUniversità di Milano
  • Maurizio Favret
    • Cattedra di Anatomia PatologicaUniversità di Brescia
  • Maria Lisa Ribero
    • Istituto d'IgieneUniversità di Milano
  • Francesco Callea
    • Servizio di Anatomia Patologica I Spedali Civili di Brescia
  • Claudia Martelli
  • Antonella Savio
    • Servizio di Anatomia Patologica Ospedale S. Orsola
  • Paola Trevisi
  • Giuseppe Nardi

DOI: 10.1023/A:1013747228572

Cite this article as:
Donato, F., Gelatti, U., Tagger, A. et al. Cancer Causes Control (2001) 12: 959. doi:10.1023/A:1013747228572


Objective: Intrahepatic cholangiocarcinoma (ICC) is a rare type of primary liver cancer (PLC) arising from intrahepatic bile ducts. We carried out a case–control study to assess the association between ICC and hepatitis B and C virus (HBV and HCV) infections, alcohol intake, and hepatolithiasis in Brescia, North Italy. Methods: Among 370 subjects with histology-based diagnosis of PLC who were resident in the area and hospitalized in 1995–2000, 26 (7%) ICC cases were identified. A total of 824 subjects unaffected by hepatic diseases and frequency-matched with PLC cases by age, sex, date, and hospital of admission were recruited as controls. Results: Among ICC cases the mean age was 65 years, 80.8% were males, and 38.5% had cirrhosis. Seropositivity for anti-HCV, HBsAg, alcohol intake > 80 g/day and history of hepatolithiasis were found in 25%, 13%, 23.1%, and 26.9% of ICC cases and in 5.8%, 6.7%, 32.9%, and 10.6% of controls, respectively. The odds ratios adjusted for demographic factors by logistic regression (95% confidence interval; 95% CI) were 9.7 (1.6–58.9) for anti-HCV, 2.7 (0.4–18.4) for HBsAg, and 6.7 (1.3–33.4) for hepatolithiasis, whereas no association was found with alcohol drinking. Conclusions: HCV and hepatolithiasis may be risk factors for ICC in Western countries.

hepatitis B virus hepatitis C virus hepatolithiasis intrahepatic cholangiocarcinoma

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© Kluwer Academic Publishers 2001