Article

Biotechnology Letters

, Volume 23, Issue 23, pp 1953-1956

First online:

Large-scale separation of magnetic bioaffinity adsorbents

  • Ivo ŠafaříkAffiliated withLaboratory of Biochemistry and Microbiology, Institute of Landscape Ecology
  • , Lucie PtáčkováAffiliated withLaboratory of Biochemistry and Microbiology, Institute of Landscape Ecology
  • , Mirka ŠafaříkováAffiliated withLaboratory of Biochemistry and Microbiology, Institute of Landscape Ecology

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Abstract

Flat magnetic separator was used to separate magnetic bioaffinity adsorbents from litre volumes of suspensions. Both magnetic cross-linked erythrocytes and magnetic chitosan were efficiently separated; at least 95% adsorbent recovery was achieved at maximum flow rate (1680 ml min−1). Using this system low amounts of trypsin were concentrated from large sample volumes using magnetic erythrocytes as affinity adsorbent.

flat magnetic separator magnetic adsorbents magnetic separation