Journal of Bioenergetics and Biomembranes

, Volume 33, Issue 6, pp 469–474

ABC Proteins of Leishmania

  • Danielle Légaré
  • Stéphane Cayer
  • Ajay K. Singh
  • Dave Richard
  • Barbara Papadopoulou
  • Marc Ouellette
Article

DOI: 10.1023/A:1012870904097

Cite this article as:
Légaré, D., Cayer, S., Singh, A.K. et al. J Bioenerg Biomembr (2001) 33: 469. doi:10.1023/A:1012870904097

Abstract

ABC proteins were first characterized in the protozoan parasite Leishmania while studying mechanisms of drug resistance. PGPA is involved in resistance to arsenite and antimonite and it most likely confers resistance by sequestering metal–thiol conjugates into an intracellular vesicle. PGPA is part of gene family with at least four more members which are in search of a function. Leishmania also contains a P-glycoprotein, homologous to the mammalian MDR1, that is involved in multidrug resistance. The ongoing genome project of Leishmania has pinpointed several novel ABC transporters and experiments are carried out to study the function of the ABC proteins in drug resistance and in host–pathogen interactions.

Leishmania ABC proteins efflux drug resistance glutathione trypanothione sequestration 

Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • Danielle Légaré
  • Stéphane Cayer
  • Ajay K. Singh
  • Dave Richard
  • Barbara Papadopoulou
  • Marc Ouellette

There are no affiliations available