Bulletin of Experimental Biology and Medicine

, Volume 132, Issue 1, pp 675–677

Role of Cystatin C and Cysteine Proteinases in the Development of Mouse LS-Lymphosarcoma

Authors

  • O. N. Poteryaeva
    • Institute of PhysiologySiberian Division of the Russian Academy of Medical Sciences
    • Institute of BiochemistrySiberian Division of the Russian Academy of Medical Sciences
    • Institute of Cytology and GeneticsSiberian Division of the Russian Academy of Sciences
  • O. V. Falameeva
    • Institute of PhysiologySiberian Division of the Russian Academy of Medical Sciences
    • Institute of BiochemistrySiberian Division of the Russian Academy of Medical Sciences
    • Institute of Cytology and GeneticsSiberian Division of the Russian Academy of Sciences
  • S. Ya. Zhanaeva
    • Institute of PhysiologySiberian Division of the Russian Academy of Medical Sciences
    • Institute of BiochemistrySiberian Division of the Russian Academy of Medical Sciences
    • Institute of Cytology and GeneticsSiberian Division of the Russian Academy of Sciences
  • I. G. Svechnikova
    • Institute of PhysiologySiberian Division of the Russian Academy of Medical Sciences
    • Institute of BiochemistrySiberian Division of the Russian Academy of Medical Sciences
    • Institute of Cytology and GeneticsSiberian Division of the Russian Academy of Sciences
  • T. A. Korolenko
    • Institute of PhysiologySiberian Division of the Russian Academy of Medical Sciences
    • Institute of BiochemistrySiberian Division of the Russian Academy of Medical Sciences
    • Institute of Cytology and GeneticsSiberian Division of the Russian Academy of Sciences
  • V. I. Kaledin
    • Institute of PhysiologySiberian Division of the Russian Academy of Medical Sciences
    • Institute of BiochemistrySiberian Division of the Russian Academy of Medical Sciences
    • Institute of Cytology and GeneticsSiberian Division of the Russian Academy of Sciences
Article

DOI: 10.1023/A:1012584429734

Cite this article as:
Poteryaeva, O.N., Falameeva, O.V., Zhanaeva, S.Y. et al. Bulletin of Experimental Biology and Medicine (2001) 132: 675. doi:10.1023/A:1012584429734

Abstract

The growth of LS-lymphosarcoma in CBA mice was accompanied by a decrease in the content of the major extracellular inhibitor cystatin C in the tumor, plasma and, to a lesser extent, in tissued not involved in tumor process (liver and spleen). Cyclophosphamide in a dose of 50 mg/kg prolonged the life-span of animals and decreased tumor size by 80%. Cathepsin B and L activities in the tumor tissue increased by 3 and 7 times, respectively. Cystatin C content in the tumor tissue, spleen, and plasma also increased. Cystatin C assay in tumor tissue and plasma helps to predict the rate of tumor growth and to evaluate the efficiency of antitumor therapy.

cystatin Ccysteine proteinasesLS-lymphosarcomacyclophosphamide

Copyright information

© Plenum Publishing Corporation 2001