Article

Bulletin of Experimental Biology and Medicine

, Volume 132, Issue 1, pp 675-677

First online:

Role of Cystatin C and Cysteine Proteinases in the Development of Mouse LS-Lymphosarcoma

  • O. N. PoteryaevaAffiliated withInstitute of Physiology, Siberian Division of the Russian Academy of Medical SciencesInstitute of Biochemistry, Siberian Division of the Russian Academy of Medical SciencesInstitute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
  • , O. V. FalameevaAffiliated withInstitute of Physiology, Siberian Division of the Russian Academy of Medical SciencesInstitute of Biochemistry, Siberian Division of the Russian Academy of Medical SciencesInstitute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
  • , S. Ya. ZhanaevaAffiliated withInstitute of Physiology, Siberian Division of the Russian Academy of Medical SciencesInstitute of Biochemistry, Siberian Division of the Russian Academy of Medical SciencesInstitute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
  • , I. G. SvechnikovaAffiliated withInstitute of Physiology, Siberian Division of the Russian Academy of Medical SciencesInstitute of Biochemistry, Siberian Division of the Russian Academy of Medical SciencesInstitute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
  • , T. A. KorolenkoAffiliated withInstitute of Physiology, Siberian Division of the Russian Academy of Medical SciencesInstitute of Biochemistry, Siberian Division of the Russian Academy of Medical SciencesInstitute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
  • , V. I. KaledinAffiliated withInstitute of Physiology, Siberian Division of the Russian Academy of Medical SciencesInstitute of Biochemistry, Siberian Division of the Russian Academy of Medical SciencesInstitute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

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Abstract

The growth of LS-lymphosarcoma in CBA mice was accompanied by a decrease in the content of the major extracellular inhibitor cystatin C in the tumor, plasma and, to a lesser extent, in tissued not involved in tumor process (liver and spleen). Cyclophosphamide in a dose of 50 mg/kg prolonged the life-span of animals and decreased tumor size by 80%. Cathepsin B and L activities in the tumor tissue increased by 3 and 7 times, respectively. Cystatin C content in the tumor tissue, spleen, and plasma also increased. Cystatin C assay in tumor tissue and plasma helps to predict the rate of tumor growth and to evaluate the efficiency of antitumor therapy.

cystatin C cysteine proteinases LS-lymphosarcoma cyclophosphamide