Digestive Diseases and Sciences

, Volume 46, Issue 11, pp 2470–2474

Acute Pancreatitis: Does Gender Matter?

  • Paul Georg Lankisch
  • Christine Assmus
  • Dirk Lehnick
  • Patrick Maisonneuve
  • Albert B. Lowenfels
Article

DOI: 10.1023/A:1012332121574

Cite this article as:
Lankisch, P.G., Assmus, C., Lehnick, D. et al. Dig Dis Sci (2001) 46: 2470. doi:10.1023/A:1012332121574

Abstract

In a number of gastrointestinal and nongastrointestinal diseases, gender has been proven to be an independent risk factor for severity. To determine whether this holds true for severity in acute pancreatitis is the aim of our study. This paper derives from a prospective study on the epidemiology of acute pancreatitis, which included 274 patients (172 male and 102 female) with a first attack of the disease. Severity parameters were: Atlanta criteria (arterial Po2 ≤ 60 mm Hg, and serum creatinine on admission >2 mg/dl after rehydration); Ranson's and Imrie's prognostic factors; APACHE II score; Balthazar-scored contrast-enhanced computed tomography (CT) results obtained within 72 hr of admission; days spent in the intensive care unit and total hospital stay; the necessity for artificial ventilation, dialysis, or surgery; and mortality. As already known, there is a significant association between gender and etiology of pancreatitis in general. Not surprisingly, the men in our study had alcohol-induced acute pancreatitis more frequently than women, whereas biliary pancreatitis predominated among the women. As for severity, there was no significant association between gender and any of the severity parameters with a few minor exceptions: longer hospital stays, higher Imrie scores and more pseudocysts for women, and more necroses in women with idiopathic pancreatitis. Thus, gender is no independent risk factor for the severity and outcome of acute pancreatitis.

acute pancreatitisgenderetiologyprognostic scoresseveritymortality

Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • Paul Georg Lankisch
    • 1
  • Christine Assmus
    • 1
  • Dirk Lehnick
    • 2
  • Patrick Maisonneuve
    • 3
  • Albert B. Lowenfels
    • 4
  1. 1.Department of Internal MedicineMunicipal Clinic of LüneburgLüneburgGermany
  2. 2.Institute for Statistics and EconometricsUniversity of GöttingenGöttingenGermany
  3. 3.European Institute of OncologyMilanoItaly
  4. 4.New York Medical CollegeValhallaUSA