Journal of Neuro-Oncology

, Volume 53, Issue 2, pp 129–147

Biological Mechanisms of Glioma Invasion and Potential Therapeutic Targets

  • Berit Bølge Tysnes
  • Rupavathana Mahesparan

DOI: 10.1023/A:1012249216117

Cite this article as:
Bølge Tysnes, B. & Mahesparan, R. J Neurooncol (2001) 53: 129. doi:10.1023/A:1012249216117


The current understanding of glioma biology reveals targets for anti-invasive therapy which include manipulations of extracellular matrix and receptors, growth factors and cytokines, proteases, cytoskeletal components, oncogenes and tumor suppressor genes. A better understanding of the complex regulation and the signalling molecules involved in glioma invasion is still needed in order to design new and effective treatment modalities towards invasive tumor cells. Representative and valid in vitro experimental systems and animal models of gliomas are necessary for the characterization of the invasive phenotype and further development of anti-invasive therapy. In the future, it will probably be important to move from comparative genomic modelling through protein characterization based on advanced proteomic techniques to analyse tissue samples, where the aim for gliomas should be to compare invaded and non-invaded tissue. This will hopefully render promising new therapeutic targets for gliomas.

glioma invasionbiological mechanismsexperimental modelsanti-invasive therapytherapeutic targetsinvasive phenotype

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Berit Bølge Tysnes
    • 1
  • Rupavathana Mahesparan
    • 1
  1. 1.Department of Anatomy and Cell BiologyUniversity of BergenBergenNorway