Biotechnology Letters

, Volume 23, Issue 17, pp 1385–1389

Hepatocyte-specific porous polymer-scaffolds of alginate/galactosylated chitosan sponge for liver-tissue engineering

Authors

  • Jun Yang
    • Department of Biomolecular EngineeringTokyo Institute of Technology
  • Teak Woong Chung
    • Bio Quest Research Co. Ltd.
  • Masato Nagaoka
    • Department of Biomolecular EngineeringTokyo Institute of Technology
  • Mitsuaki Goto
    • Bio Quest Research Co. Ltd.
  • Chong-Su Cho
    • School of Agricultural BiotechnologySeoul National University
  • Toshihiro Akaike
    • Department of Biomolecular EngineeringTokyo Institute of Technology
Article

DOI: 10.1023/A:1011600414225

Cite this article as:
Yang, J., Woong Chung, T., Nagaoka, M. et al. Biotechnology Letters (2001) 23: 1385. doi:10.1023/A:1011600414225

Abstract

Porous scaffolds of alginate/galactosylated chitosan (ALG/GC) sponges were prepared by lyophilization for liver-tissue engineering. Primary hepatocytes in ALG/GC sponges showed higher cell attachment and viability than in alginate alone owing to the specific interaction of the asialoglycoprotein receptors on hepatocyte with the galactose residues on ALG/GC sponges. Improvements in spheroid formation and long-term liver-specific functions of the immobilized hepatocyte were also observed in ALG/GC sponge.

alginategalactosylated chitosanhepatocyteliver-tissue engineeringsponge
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Copyright information

© Kluwer Academic Publishers 2001