Cancer Causes & Control

, Volume 12, Issue 3, pp 279–287

Light in the Built Environment: Potential role of Circadian Disruption in Endocrine Disruption and Breast Cancer

Article

DOI: 10.1023/A:1011237000609

Cite this article as:
Stevens, R.G. & Rea, M.S. Cancer Causes Control (2001) 12: 279. doi:10.1023/A:1011237000609

Abstract

Life in industrialized societies is primarily life inside buildings. Illumination from electric lighting in the built environment is quite different from solar radiation in intensity, spectral content, and timing during the 24-hour daily period. Humans evolved over millions of years with the day–night pattern of solar radiation as the primary circadian cue. This pattern maintained a 24-hour rhythm of melatonin release, as well as a host of other physiological rhythms including the sleep–wake cycle. Electric lighting in the built environment is generally more than sufficient for visual performance, but may be inappropriate for the maintenance of normal neuroendocrine rhythms in humans; e.g., insufficient during the day and too much at night. Lighting standards and engineering stress visual performance, whereas circadian function is not currently emphasized. The molecular biological research on the circadian clock and on mechanisms of phototransduction makes it clear that light for vision and light for circadian function are not identical systems. In particular, if electric lighting as currently employed contributes to `circadian disruption' it may be an important cause of `endocrine disruption' and thereby contribute to a high risk of breast cancer in industrialized societies.

breast cancer buildings circadian disruption endocrine disruption light 

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  1. 1.Department of Community MedicineUniversity of Connecticut Health CenterFarmingtonUSA
  2. 2.Rensselaer Polytechnic InstituteLighting Research Center (LRC)TroyUSA

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