Cancer Causes & Control

, Volume 12, Issue 4, pp 325–334

Smoking and Hematolymphopoietic Malignancies

Authors

  • E. Stagnaro
    • Epidemiology Unit of National Cancer Research Institute
  • V. Ramazzotti
    • National Cancer Institute Regina Elena
  • P. Crosignani
    • Epidemiology Unit of National Cancer Institute
  • A. Fontana
    • Local Health Unit
  • G. Masala
    • Epidemiology Unit of CSPO, Az. Ospedaliera Careggi
  • L. Miligi
    • Epidemiology Unit of CSPO, Az. Ospedaliera Careggi
  • O. Nanni
    • Oncologic Institute Romagnolo
  • M. Neri
    • Epidemiology Unit of National Cancer Research Institute
  • S. Rodella
    • U. O. Miglioramento per la Qualità
  • A. Seniori Costantini
    • Epidemiology Unit of CSPO, Az. Ospedaliera Careggi
  • R. Tumino
    • Cancer Registry
  • C. Viganò
    • Epidemiology Unit of National Cancer Institute
  • C. Vindigni
    • Pathology InstituteUniversity of Siena
  • P. Vineis
    • Cancer Epidemiology UnitUniversity of Turin
Article

DOI: 10.1023/A:1011216102871

Cite this article as:
Stagnaro, E., Ramazzotti, V., Crosignani, P. et al. Cancer Causes Control (2001) 12: 325. doi:10.1023/A:1011216102871

Abstract

Objective: Tobacco use is the most prominent cause of respiratory cancers. Little is known, however, about the influence of smoking on hematolymphopoietic malignancies. To evaluate this relation, a population-based case–control study was carried out in 12 areas of Italy. Methods: Detailed interviews on tobacco smoking habits were administered to 1450 non-Hodgkin's lymphoma (NHL), 365 Hodgkin's disease (HD), 270 multiple myeloma (MM), and 649 leukemia (LEU) patients occurring from 1990 to 1993, and 1779 population controls. Results: We found a slightly increased risk for NHL in smokers (odds ratio 1.2, 95% confidence interval 1.0–1.4 for ever smokers), but a consistent positive association was shown only for follicular NHL. In this subtype, a significant excess risk was observed for ever versus never smokers, after adjustment for gender, age, geographic residence, education, and respondent (OR = 1.8, 95%, CI 1.3–2.7), with a positive exposure–response gradient for smoking duration (p<0.01). The risk for follicular NHL was significantly elevated only among women, with ever smokers showing OR = 2.3 (CI 1.4–3.8), while for men we found OR = 1.3 (CI 0.69–2.3). No major differences were shown according to age. Female subjects also showed significant positive exposure–response trends for duration. Conclusion: Cigarette smoking could be a risk factor for follicular NHL among women. For HD, MM, or LEU, no clear association was observed.

case– control studiesleukemialymphomamultiple myelomasmoking
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© Kluwer Academic Publishers 2001