Melanoma risk in relation to height, weight, and exercise (United States)
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Height and weight and derivations thereof are positively associated with a number of cancers. While several authors have reported an increased risk of melanoma among people at the higher extremes of these measures, the association has not been fully explored. New cases of primary cutaneous melanoma in 1997 in western Washington State (n = 386) were compared to controls selected by random-digit dialing (n = 727). Each study participant completed a telephone survey, and data were collected on height, weight, sun-related melanoma risk factors, demographic characteristics, as well as habits such as diet and exercise. Risk of melanoma was analyzed by logistic regression with adjustment for age, hair color, lifetime sun exposure, and fruit and vegetable intake. An excess risk of melanoma was identified in men in the upper quartiles of height (OR = 2.4, 95% confidence interval (CI) = 1.3–4.5), weight (OR = 2.8, CI = 1.5–5.2), and body surface area (OR = 2.8, CI = 1.5–5.1) vs. the lowest quartiles. In women, no association was present for any anthropometric measure. In addition, we found that men and women exercising five to seven days per week were at a decreased risk of melanoma (OR = 0.7, CI = 0.5–1.0). The anthropometric findings are largely consistent with previous studies, while this is the first report of an association of exercise with melanoma risk. The mechanisms for the effect of exercise and for the difference between men and women in the effect of anthropometric factors are unknown. Future research in basic and epidemiologic science should focus on biochemical or behavioral explanations for these observations.
- Albanes D, Winick M (1988) Are cell number and cell proliferation risk factors for cancer? J Natl Cancer Inst 80: 772–774.
- Ross MH, Bras G (1965) Tumor incidence patterns and nutrition in the rat. J Nutr 87: 245–260.
- Ross MH, Bras G (1971) Lasting influence of early caloric restriction on prevalence of neoplasms in the rat. J Natl Cancer Inst 47: 1095–1113.
- Winick M, Noble A (1966) Cellular response in rats during malnutrition at various ages. J Nutr 89: 300–306.
- Frankel S, Gunnell DJ, Peters TJ, Maynard M, Davey Smith G (1998) Childhood energy intake and adult mortality from cancer: the Boyd Orr Cohort Study. BMJ 316: 499–504.
- Dubin N, Moseson M, Pasternack BS (1986) Epidemiology of malignant melanoma: pigmentary traits, ultraviolet radiation, and the identification of high-risk populations. Recent Results Cancer Res 102: 56–75.
- Thune I, Olsen A, Albrektsen G, Tretli S (1993) Cutaneous malignant melanoma: association with height, weight and body-surface area: a prospective study in Norway. Int J Cancer 55: 555–561.
- Wang Y, Moss J, Thisted R (1992) Predictors of body surface area. J Clin Anesth 4: 4–10.
- McTiernan A, Ulrich C, Slate S, Potter J (1998) Physical activity and cancer etiology: associations and mechanisms. Cancer Causes Control 9: 487–509.
- Elwood JM, Gallagher RP, Worth AJ, Wood WS, Pearson JC (1987) Etiological differences between subtypes of cutaneous malignant melanoma: Western Canada Melanoma Study. J Natl Cancer Inst 78: 37–44.
- Ries L, Eisner M, Kosary C, et al. (2000) SEER Cancer Statistics Review, 1973–1997. Bethesda, MD: National Cancer Institute.
- Troldahl V, Carter R (1964) Random selection of respondents within households in phone surveys. J Market Res 1: 71–76.
- Du Bois D, Du Bois EF (1916) A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med 17: 863–871.
- Albanes D, Jones DY, Schatzkin A, Micozzi MS, Taylor PR (1988) Adult stature and risk of cancer. Cancer Res 48: 1658–1662.
- Hebert PR, Ajani U, Cook NR, Lee IM, Chan KS, Hennekens CH (1997) Adult height and incidence of cancer in male physicians (United States). Cancer Causes Control 8: 591–597.
- Albanes D (1990) Energy balance, body size, and cancer. Crit Rev Oncol Hematol 10: 283–303.
- Gallagher RP, Elwood JM, Hill GB, Coldman AJ, Threlfall WJ, Spinelli JJ (1985) Reproductive factors, oral contraceptives and risk of malignant melanoma: Western Canada Melanoma Study. Br J Cancer 52: 901–907.
- Holman CD, Armstrong BK, Heenan PJ (1984) Cutaneous malignant melanoma in women: exogenous sex hormones and reproductive factors. Br J Cancer 50: 673–680.
- Kirkpatrick CS, White E, Lee JA (1994) Case-control study of malignant melanoma in Washington State. II. Diet, alcohol, and obesity. Am J Epidemiol 139: 869–880.
- Le MG, Cabanes PA, Desvignes V, Chanteau MF, Mlika N, Avril MF (1992) Oral contraceptive use and risk of cutaneous malignant melanoma in a case-control study of French women. Cancer Causes Control 3: 199–205.
- Osterlind A, Tucker MA, Stone BJ, Jensen OM (1988) The Danish case-control study of cutaneous malignant melanoma. III. Hormonal and reproductive factors in women. Int J Cancer 42: 821–824.
- Ruel MT, Rivera J, Habicht JP, Martorell R (1995) Differential response to early nutrition supplementation: long-term effects on height at adolescence. Int J Epidemiol 24: 404–412.
- Juul A, Dalgaard P, Blum WF, et al. (1995) Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation. J Clin Endocrinol Metab 80: 2534–2542.
- Keenan BS, Richards GE, Ponder SW, Dallas JS, Nagamani M, Smith ER (1993) Androgen-stimulated pubertal growth: the effects of testosterone and dihydrotestosterone on growth hormone and insulin-like growth factor-1 in the treatment of short stature and delayed puberty. J Clin Endocrinol Metab 76: 996–1001.
- Grimberg A, Cohen P (2000) Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. J Cell Physiol 183: 1–9.
- Akaza H, Matsuki K, Matsushima H, Koiso K, Aso Y (1991) Stimulatory effects of growth hormone on rat bladder carcinogenesis. Cancer 68: 2418–2421.
- Beck-Friis J, von Rosen D, Kjellman BF, Ljunggren JG, Wetterberg L (1984) Melatonin in relation to body measures, sex, age, season and the use of drugs in patients with major affective disorders and healthy subjects. Psychoneuroendocrinology 9: 261–277.
- Wetterberg L, Bratlid T, von Knorring L, Eberhard G, Yuwiler A (1999) A multinational study of the relationships between nighttime urinary melatonin production, age, gender, body size, and latitude. Eur Arch Psychiatry Clin Neurosci 249: 256–262.
- Shellard SA, Whelan RD, Hill BT (1989) Growth inhibitory and cytotoxic effects of melatonin and its metabolites on human tumour cell lines in vitro. Br J Cancer 60: 288–290.
- Ying SW, Niles LP, Crocker C (1993) Human malignant melanoma cells express high-affinity receptors for melatonin: antiproliferative effects of melatonin and 6-chloromelatonin. Eur J Pharmacol 246: 89–96.
- Krotkiewski M, Bjorntorp P, Sjostrom L, Smith U (1983) Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. J Clin Invest 72: 1150–1162.
- Albanes D, Blair A, Taylor PR (1989) Physical activity and risk of cancer in the NHANES I population. Am J Public Health 79: 744–750.
- Bernstein L, Henderson BE, Hanisch R, Sullivan-Halley J, Ross RK (1994) Physical exercise and reduced risk of breast cancer in young women. J Natl Cancer Inst 86: 1403–1408.
- Kune GA, Kune S, Watson LF (1990) Body weight and physical activity as predictors of colorectal cancer risk. Nutr Cancer 13: 9–17.
- Lee IM, Manson JE, Ajani U, Paffenbarger RS, Jr., Hennekens CH, Buring JE (1997) Physical activity and risk of colon cancer: the Physicians' Health Study (United States). Cancer Causes Control 8: 568–574.
- Moradi T, Adami HO, Bergstrom R, et al. (1999) Occupational physical activity and risk for breast cancer in a nationwide cohort study in Sweden. Cancer Causes Control 10: 423–430.
- Rockhill B, Willett WC, Hunter DJ, Manson JE, Hankinson SE, Colditz GA (1999) A prospective study of recreational physical activity and breast cancer risk. Arch Intern Med 159: 2290–2296.
- Verloop J, Rookus MA, van der Kooy K, van Leeuwen FE (2000) Physical activity and breast cancer risk in women aged 20–54 years. J Natl Cancer Inst 92: 128–135.
- Melanoma risk in relation to height, weight, and exercise (United States)
Cancer Causes & Control
Volume 12, Issue 7 , pp 599-606
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- 1. Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA
- 2. University of Washington School of Medicine, Seattle, WA, USA
- 3. Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, WA, USA
- 4. Department of Medicine, Division of General Internal Medicine, University of Washington Medical Center, Seattle, WA, USA