Axonal protein synthesis and transport
- P.E. Gallant
- … show all 1 hide
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Recent evidence has challenged our ideas about the nature of axonal protein synthesis and transport. Previous metabolic labeling evidence supported the idea that all axonal proteins were synthesized in the cell body and then transported as formed cytoplasmic structures into the axon. Recent evidence suggests that neither the synthesis nor the transport of axonal proteins is that simple. Though most axonal proteins do appear to be synthesized in the neuronal cell body, a small amount of protein appears to be synthesized intra-axonally in some axons. Though small in amount, intra-axonal protein synthesis may be important functionally in some axons. Recent experiments have also begun to identify the presence of a rich array of transport motors in axons, including many members of the kinesin, dynein and myosin families. Progress is being made in identifying which cargoes are being transported by which of these motors. Finally, recent experiments have addressed an old question about whether axoplasmic proteins are transported as filamentous polymers or as soluble components in axons. The answer is that both mechanism can be used in axons. For example, neurofilament protein can move in its particulate or polymeric state, while tubulin can move in its soluble or unpolymerized state.
- BRIDGMAN, P. C. & ELKIN, L. L. (2000) Axonal myosins. Journal of Neurocytology 29, 831-841.
- CAMPENOT, R. B. & ENG, H. (2000) Protein synthesis in axons and its possible functions. Journal of Neurocytology 29, 793-798.
- GALBRAITH, J. A. & GALLANT, P. E. (2000) Axonal transport of actin and tubulin. Journal of Neurocytology 29.
- GALBRAITH, J. A., REESE, T. S., SCHLIEF, M. L. & GALLANT, P. E. (1999) Slow transport of unpolymerized tubulin and polymerized neurofilament in the squid giant axon. Proceedings of the National Academy of Science USA 96, 11589-11594.
- GRANT, P. & PANT, H. C. (2000) Neurofilament protein synthesis and phosphorylation. Journal of Neurocytology 29, 843-872.
- HARRISON, R. G. (1910) The outgrowth of the nerve fiber as a mode of protoplasmic growth. Journal of Experimental Zoology 9, 787-846.
- MOHR, E. & RICHTER, D. (2000) Axonal mRNAs: Functional significance in vertebrates and invertebrates. Journal of Neurocytology 29, 783-791.
- MURESAN, V. (2000) One axon, many kinesins: What's the logic? Journal of Neurocytology 29, 799-818.
- SHEA, T. B. (2000) Microtubule motors, phosphorylation, and axonal transport of neurofilaments. Journal of Neurocytology 29, 873-887.
- SUSALKA, S. J. & PFISTER, K. K. (2000) Cytoplasmic dynein subunit herterogeneity: Implications for axonal transport. Journal of Neurocytology 29, 819-829.
- TERASAKI, M., SCHMIDEK, A., GALBRAITH, J. A., GALLANT, P. E. & REESE, T. S. (1995) Transport of cytoskeletal elements in the squid giant axon.Proceedings of the National Academy of Science USA 92, 11500-11503.
- WALLER, A. (1851) Experiments on the section of the glossopharygeal and hypoglossal nerves of the frog, and obserations of the alterations produced thereby in the structure of the primative fibers. Philosphical Transactions of the Royal Society (London) Series B 140, 423-429.
- Axonal protein synthesis and transport
Journal of Neurocytology
Volume 29, Issue 11-12 , pp 779-782
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers
- Additional Links
- P.E. Gallant (1)
- Author Affiliations
- 1. Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, Bldg. 36 Rm. 2A-21 National Institutes of Health, Bethesda, MD, 20892, USA