Journal of Clinical Immunology

, Volume 21, Issue 4, pp 258–263

Role of Adhesion Molecules in Activation Signaling in T Lymphocytes


  • Michael L. Dustin
    • Program in Molecular Pathogenesis and Department of Pathology, Skirball Institute of Molecular MedicineNew York University School of Medicine

DOI: 10.1023/A:1010927208180

Cite this article as:
Dustin, M.L. J Clin Immunol (2001) 21: 258. doi:10.1023/A:1010927208180


The T cell and antigen-presenting cell communicate to initiate an immune response through formation of an immunological synapse. This specialized cell–cell junction is compartmentalized into adhesion molecule and T cell receptor enriched regions or SMACs. Distinct signals seem to be generated in the T cell receptor and adhesion molecule-dominated regions. This review focuses on how these distinct signaling pathways may be integrated within the T cell to set thresholds for T cell activation, proliferation, and survival.

Adhesion moleculesactivation signalingT lymphocytessynapsescell growth and survival

Copyright information

© Plenum Publishing Corporation 2001