Role of Adhesion Molecules in Activation Signaling in T Lymphocytes
- Cite this article as:
- Dustin, M.L. J Clin Immunol (2001) 21: 258. doi:10.1023/A:1010927208180
The T cell and antigen-presenting cell communicate to initiate an immune response through formation of an immunological synapse. This specialized cell–cell junction is compartmentalized into adhesion molecule and T cell receptor enriched regions or SMACs. Distinct signals seem to be generated in the T cell receptor and adhesion molecule-dominated regions. This review focuses on how these distinct signaling pathways may be integrated within the T cell to set thresholds for T cell activation, proliferation, and survival.