Journal of Clinical Immunology

, Volume 21, Issue 4, pp 258-263

First online:

Role of Adhesion Molecules in Activation Signaling in T Lymphocytes

  • Michael L. DustinAffiliated withProgram in Molecular Pathogenesis and Department of Pathology, Skirball Institute of Molecular Medicine, New York University School of Medicine

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The T cell and antigen-presenting cell communicate to initiate an immune response through formation of an immunological synapse. This specialized cell–cell junction is compartmentalized into adhesion molecule and T cell receptor enriched regions or SMACs. Distinct signals seem to be generated in the T cell receptor and adhesion molecule-dominated regions. This review focuses on how these distinct signaling pathways may be integrated within the T cell to set thresholds for T cell activation, proliferation, and survival.

Adhesion molecules activation signaling T lymphocytes synapses cell growth and survival