Neurochemical Research

, Volume 26, Issue 3, pp 191–194

Effects of Linalool on Glutamate Release and Uptake in Mouse Cortical Synaptosomes

  • L. F. Silva Brum
  • T. Emanuelli
  • D. O. Souza
  • E. Elisabetsky
Article

DOI: 10.1023/A:1010904214482

Cite this article as:
Silva Brum, L.F., Emanuelli, T., Souza, D.O. et al. Neurochem Res (2001) 26: 191. doi:10.1023/A:1010904214482

Abstract

Linalool, a monoterpene compound prevalent in essential oil of plant species traditionally used as sedatives, has been characterized as anticonvulsant in several experimental models. Linalool inhibits the binding of [3H]glutamate and [3H]dizocilpine to brain cortical membranes, indicating a participation of the glutamatergic transmission its mechanism of action. In this study, we investigated the effects of linalool on [3H]glutamate release (basal and potassium-stimulated) and [3H]glutamate uptake in mice cortical synaptosomes. Linalool significantly reduced potassium-stimulated glutamate release as well as glutamate uptake, not interfering with basal glutamate release. The data indicates that linalool may interfere with several relevant elements of the glutamatergic transmission, including detriment of the K+-stimulated glutamate release.

Linaloolanticonvulsantsglutamateuptakereleasemice

Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • L. F. Silva Brum
    • 1
    • 2
    • 4
  • T. Emanuelli
    • 2
    • 3
  • D. O. Souza
    • 2
  • E. Elisabetsky
    • 1
    • 2
  1. 1.Laboratório de Etnofarmacologia, Departamento de FarmacologiaUniversidade Federal do Rio Grande do SulPorto AlegreBrazil
  2. 2.Departamento de Bioquímica, ICBSUniversidade Federal do Rio Grande do SulBrazil
  3. 3.Departamento de Tecnologia e Ciência dos Alimentos, CCRUniversidade Federal de Santa MariaSanta MariaBrazil
  4. 4.Departamento de Farmacologia, Curso de FarmáciaUniversidade Luterana do BrasilBrazil