Article

Biotechnology Letters

, Volume 23, Issue 9, pp 667-675

First online:

An evaluation of the anti-bacterial action of ceramic powder slurries using multi-parameter flow cytometry

  • Christopher J. HewittAffiliated withCentre for Bioprocess Engineering, School of Chemical Engineering, The University of Birmingham
  • , Sanjay R. BellaraAffiliated withCentre for Bioprocess Engineering, School of Chemical Engineering, The University of Birmingham
  • , Andrea AndreaniAffiliated withCentre for Bioprocess Engineering, School of Chemical Engineering, The University of Birmingham
  • , Gerhard Nebe-von-CaronAffiliated withUnilever Research, Colworth Laboratory
  • , Caroline M. McFarlaneAffiliated withCentre for Bioprocess Engineering, School of Chemical Engineering, The University of Birmingham

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Abstract

Multi-parameter flow cytometric techniques have been used to study the effects of three ceramic powders CaO, MgO and ZnO on the physiology of individual, exponentially growing E. coli cells. Whilst all three powders inhibited reproductive growth, depending on their concentration, the mechanism of action of CaO and MgO was different to that of ZnO as shown by fluorescent staining techniques developed in our laboratory.

ceramic powder slurries Escherichia coli membrane integrity membrane potential multi-parameter flow cytometry