Antonie van Leeuwenhoek

, Volume 78, Issue 3, pp 399–405

Rare genera of actinomycetes as potential producers of new antibiotics


  • Ameriga Lazzarini
    • Biosearch Italia S.p.A
  • Linda Cavaletti
    • Biosearch Italia S.p.A
  • Giorgio Toppo
    • Biosearch Italia S.p.A
  • Flavia Marinelli
    • Biosearch Italia S.p.A

DOI: 10.1023/A:1010287600557

Cite this article as:
Lazzarini, A., Cavaletti, L., Toppo, G. et al. Antonie Van Leeuwenhoek (2000) 78: 399. doi:10.1023/A:1010287600557


A literature survey covering more than twenty-three thousand bioactive microbial products including eight thousand antiinfectives demonstrated the increasing relevance of the so called 'rare' actinomycetes as a source of new antibiotics. Past and present efforts in the isolation of rare actinomycetes have enriched the Biosearch Italia Strain Collection with more than twenty thousand strains, showing that, when selective isolation methods are developed and extensively applied, some genera, such as Actinomadura, Actinoplanes, Micromonospora, Microtetraspora, are not rare at all and can be recovered from many soil samples. The current focus is on the isolation of members of Streptosporangiaceae family, given their promising chemical diversity.

actinomycetesantibioticsmicrobial product databasestrain isolationStreptosporangiaceae

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© Kluwer Academic Publishers 2000