Cloning and Characterization of KLHL5, a Novel Human Gene Encoding a Kelch-Related Protein with a BTB Domain
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- Wang, S., Zhou, Z., Ying, K. et al. Biochem Genet (2001) 39: 227. doi:10.1023/A:1010203114697
Most kelch family proteins contain two conserved domains, the BTB domain and the kelch repeat domain. Here we describe the cloning and characterization of a novel human KLHL5 gene. The 3488 bp cDNA encodes a kelch family protein homologous to the Drosophila kelch protein. It also contains the two conserved domains. Northern blot analysis reveals a single transcript. It is abundantly expressed in ovary, adrenal gland, and thyroid and less abundantly expressed in trachea, prostate, testis, lymph node, and spinal cord. KLHL5 was mapped to 4p13–4p15.1.