Biochemical Genetics

, Volume 39, Issue 7, pp 227–238

Cloning and Characterization of KLHL5, a Novel Human Gene Encoding a Kelch-Related Protein with a BTB Domain

  • Shu Wang
  • Zongxiang Zhou
  • Kang Ying
  • Rong Tang
  • Yan Huang
  • Chaoqun Wu
  • Yi Xie
  • Yumin Mao
Article

DOI: 10.1023/A:1010203114697

Cite this article as:
Wang, S., Zhou, Z., Ying, K. et al. Biochem Genet (2001) 39: 227. doi:10.1023/A:1010203114697

Abstract

Most kelch family proteins contain two conserved domains, the BTB domain and the kelch repeat domain. Here we describe the cloning and characterization of a novel human KLHL5 gene. The 3488 bp cDNA encodes a kelch family protein homologous to the Drosophila kelch protein. It also contains the two conserved domains. Northern blot analysis reveals a single transcript. It is abundantly expressed in ovary, adrenal gland, and thyroid and less abundantly expressed in trachea, prostate, testis, lymph node, and spinal cord. KLHL5 was mapped to 4p13–4p15.1.

human KLHL5 gene kelch BTB domain BTB/kelch protein actin binding 

Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  • Shu Wang
    • 1
  • Zongxiang Zhou
    • 1
  • Kang Ying
    • 1
  • Rong Tang
    • 1
  • Yan Huang
    • 1
  • Chaoqun Wu
    • 1
  • Yi Xie
    • 1
  • Yumin Mao
    • 1
  1. 1.Institute of Genetics, School of Life ScienceFudan UniversityShanghaiPeople's Republic of China

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