, Volume 3, Issue 2, pp 87–91

New Concepts in Activation of the Clotting Cascade in Sepsis

  • Joost C.M. Meijers
  • Bonno N. Bouma

DOI: 10.1023/A:1009887130463

Cite this article as:
Meijers, J.C. & Bouma, B.N. Sepsis (1999) 3: 87. doi:10.1023/A:1009887130463


Systemic infection leads to activation of the coagulation system. The presence of endotoxins results in exposure of tissue factor. Tissue factor-mediated initiation of coagulation results in the generation of thrombin for fibrin formation. Thrombin formation continues after fibrin formation via feedback activation of factor XI, thereby propagating the intrinsic pathway of coagulation. The extra thrombin that is formed can lead to additional fibrin formation and protection of the fibrin clot from fibrinolysis. The activation of the coagulation system, with at the same time not fully working control mechanisms, induces a severe procoagulant state in sepsis.

coagulationsepsisfibrinolysistissue factor

Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Joost C.M. Meijers
    • 1
  • Bonno N. Bouma
    • 1
  1. 1.Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Center, Utrecht, and Institute of BiomembranesUtrecht UniversityUtrechtthe Netherlands