Lifetime Data Analysis

, Volume 5, Issue 2, pp 99–112

Computing the Cox Model for Case Cohort Designs

  • Terry M. Therneau
  • Hongzhe Li

DOI: 10.1023/A:1009691327335

Cite this article as:
Therneau, T.M. & Li, H. Lifetime Data Anal (1999) 5: 99. doi:10.1023/A:1009691327335


Prentice (1986) proposed a case-cohort design as an efficient subsampling mechanism for survival studies. Several other authors have expanded on these ideas to create a family of related sampling plans, along with estimators for the covariate effects. We describe how to obtain the proposed parameter estimates and their variance estimates using standard software packages, with SAS and SPLUS as particular examples.

Cox modelcase-cohort designjackknife estimaterobust variancefinite sampling

Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Terry M. Therneau
    • 1
  • Hongzhe Li
    • 2
  1. 1.Section of BiostatiscticsMayo FoundationRochester
  2. 2.Rowe Program in GeneticsUC Davis School of MedicineDavis