Mollinedo F, Fernández Luna JL, Gajate C, et al. Selective induction of apoptosis in cancer cells by the ether ET-18–OCH3 (edelfosine): molecular structure requirements, cellular uptake, and protection by bcl-2 and bcl xL. Cancer Res 1997; 57: 1320–1328.
Shemtov MM, Cheng DL-W, Kong L, et al. LAK cell mediated apoptosis of human bladder cancer cells involves a pH-dependent endonuclease system in the cancer cell: possible mechanism of BCG therapy. J Urology 1995; 154: 269–274.
Rebollo A, Gómez J, de Aragón AM, Lastres P, Silva A, Pérez-Sala D. Apoptosis induced by IL-2 withdrawal is associated with an intracellular acidification. Exp Cell Res 1995; 218: 581–585.
Pérez-Sala D, Collado-Escobar D, Mollinedo F. Intracellular alkalinization supresses lovastatin-induced apoptosis in HL60 cells through the inactivation of a pH-dependent endonuclease. J Biol Chem 1995; 270: 6235–6242.
Li J, Eastman A. Apoptosis in an interleukin-2–dependent cytotoxic T lymphocyte cell line is associated with intracellular acidification. Role of the Na+/H+-Antiport. J Biol Chem 1995; 270: 3203–3211.
Reynolds JE, Li JF, Craig RW, Eastman, A. BCL-2 and MCL-1 expression in chinese hamster ovary cells inhibits intracellular acidification and apoptosis induced by staurosporine. Exp Cell Res 1996; 225: 430–436.
Wolf CM, Reynolds JE, Morana SJ, Eastman, A. The temporal relationship between protein phosphatase. ICE/CED-3 proteases, intracellular acidification, and DNA fragmentation in apoptosis. Exp Cell Res 1997; 230(1): 22–27.
Angoli D, Delia D, Wank E. Early cytoplasmatic acidification un retinamide-mediated apoptosis of human leukemia cells. Biochem Biophys Res Com 1996; 229(2): 681–685.
Li J, Eastman A. Apoptosis in an interleukin-2–dependent cytotoxic T lympohocyte cell line is associated with intracellular acidification, Role of the Na.
/-antiport. J Biol Chem 1995; 270(2): 3203–3211.
Harguindey S, Catalán J, Antón-Aparicio LM. Possible exploitation of an H+-related mechanism in the treatment of breast and colon tumors: a new approach to the adjuvant treatment of cancer. In: Crane FL, Morré DJ, L¨ow H, eds. Plasma Oxidoreductases in Control of Animal and Plant Growth. NewYork: Plenum Press 1988: 415–418.
Maidhorn RPE, Cragoe EJ Jr, Tannock IF. Therapeutic potential of analogues of amiloride: inhibition to the regulation of intracellular pH as a possible mechanism of tumor selective therapy. Br J Cancer 1993; 67: 297–303.
Harguindey S, Pedraz JL, García Cañero R., Pérez de Diego J, Cragoe, EJ. Jr. Hydrogen ion-dependent oncogenesis and parallel new avenues to cancer prevention and treatment using aH+-mediated unifying approach: pH-related and pH-unrelated mechanisms. Critical Rev Oncogenesis 1995; 6(1): 1–33.
Harguindey, S. Use of Na+/H+ antiporter inhibitors as a novel approach to cancer treatment. In: Cragoe EJ Jr, Kleyman ThR, Simchowitz L, eds.Amiloride and its Analogs: Unique Cation Transport Inhibitors. New York: VCH Publishers Inc. 1992: 317–334.
Harguindey S, Cragoe EJ Jr. The Na+/H+ antiporter in oncology in the light of the spontaneous regression of cancer and cell metabolism. Med Hypotheses 1992; 39: 229–237.
Keizer HG, Joenje H. Increased cytosolic pH in multidrugresistant human lung tumor cells: effect of verapamil. J Natl Cancer Inst 1989; 81: 706–709.
Simon S, Roy D, Schindler M. Intracellular pH and the control of multidrug resistance. Proc Natl Acad Sci USA 1994; 91: 1128–1132.
Hamilton G, Cosentini EP, Teleky B, et al. The multidrugresistance modifiers verapamil, cyclosporine A and tamoxifen induce an intracellular acidification in colon carcinoma cell lines in vitro. Anticancer Res 1993; 13(6A): 2059–2063.
Oberhaensli RD, Bore PG, Rampling RP, Hilton-Jones D, Hands LJ, Radda GK. Biochemical investigation of human tumors in vivo with phosphorus-31 magnetic resonance spectroscopy. Lancet 1986; 2: 8–11.
Perona R, Portillo F, Giraldez F, Serrano R. Transformation and pH homeostasis expressing a yeast H+-ATPase containing site-directed mutations. Mol Cell Biology 1990; 10(8): 4110–4115.
Besson P, Goré J, Vincent E, Hoinard C, Bougnoux, P. Inhibition of the Na+/H+ exchanger activity by an alkyllysophospholipid analogue in a human breast cancer cell line. Biochem Pharmacol 1996; 51: 1153–1158.
Weinsburg JH, Curcio M, Caron PC, et al. The multidrugresistant phenotype confers immunological resistance. J Exp Med 1996; 183(6): 2699–2704.
Stotzer OJ, Nussler V, Darsow M, et al. The role of bcl-2 and bax expression ratio for predicting response to chemotherapy in acute myleoblastic leukemia. Proc Annu Meet Am Assoc Cancer Res 1996; 37: A2169.