Wyllie AH, Beattie GJ, Hargreaves AD. Chromatin changes in apoptosis. Histochem J 1981; 13: 681.
Nicotera P, Zhivitovsky B, Orrenius S. Nuclear calcium transport and the role of calcium in apoptosis. Cell Calcium 1994; 16: 279–288.
McConkey DJ, Hartzell P, Nicotera P, Orrenius S. Calcium activated DNA fragmentation kills immature thymocytes. Faseb J 1989; 3: 1839–1849.
McConkey DJ, Nicotera P, Hartzell P, Bellomo G, Wyllie AH, Orrenius S. Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration. Biochem Biophys 1989; 269: 365–370.
Duke RC, Witter RZ, Nash PB, Young JDE, Ojcius DM. Cytolysis mediated by ionophores and pore-forming agents: role of intracellular calcium in apoptosis. Faseb J 1994; 8: 237–246.
Cotter TG, Fernanded RS. Activation of a calcium magnesium independent endonuclease in human leukemic cell apoptosis. Anticancer Res 1993; 13: 1253–1259.
Orrenius S, McCabe MJ, Nicotera P. Ca2+-dependent mechanisms of cytotoxicity and programmed cell death. Toxicol Lett 1992; 64/65: 357–364.
Walker PR, Sikorska M. New aspects of the mechanism of DNA fragmentation in apoptosis. Biochem Cell Biol 1997; 75: 287–299.
Cain K, Salmaan H, Hussain I, Kokileva L, Cohen GM. DNA cleavage in rat liver nuclei activated by Mg2+ or Ca2+ + Mg is inhibited by a variety of structurally unrelated inhibitors. Biochem Cell Biol 1994; 72: 631–638.
McCarthy JV, Cotter TG. Cell shrinkage and apoptosis: a role for potassium and sodium ion efflux. Cell Death and Differentiation 1997; 4: 756–770.
Dallaporta B, Hirsch T, Susin SA, et al. Potassium leakage during the apoptotic degradation phase. J Immunol 1998; 160: 5605–5615.
Bortner CD, Huges FM, Cidlowski JA. A primary role for K+ and Na+ efflux in the activation of apoptosis. J Biol Chem 1997; 272: 32436.
Hoffman EK, Simonsen LO. Membrane mechanisms in volume and pH regulation in vertebrate cell. Physiol Rev 1989; 69: 315–382.
Muchmore SW, Sattler M, Liang H, et al. X-ray and NMR structure of human Bcl-
XL, an inhibitor of programmed cell death. Nature 1996; 381: 335.
Minn AJ, Vélez P, Schendel SL, et al. Bcl-XL forms ion an ion channel in synthetic lipid membranes. Nature 1997; 385: 353–357.
Singh RP, Al-Rubeai M, Gregory CD, Emery AN. Cell death in bioreactors: a role for apoptosis. Biotechnol Bioeng 1994; 44: 720.
Al-Rubeai M, Emery AN, Chalder S. Flow cytometric study of cultured mammalian cells. J Biotechnol 1991; 19: 67.
Ishaque A, Al-Rubeai M. Use of intracellular pH and annexin-V flow cytometric assays to monitor apoptosis and its suppression by bcl-2 over-expression in hybridoma cell culture. J Immunol Methods 1998; 221: 43–57.
Welsh JP, Al-Rubeai M. The Relationship between Intracellular pH and Cell Cycle in Cultured Animal Cells using SNARF-1 Indicator. Flow Cytometry Applications in Culture, In: Al-Rubeai M and Emery AN, eds., Marcel Dekker, 1996: 163–175.
Hampton MB, Vanags DM, Pörn-Ares I, Orrenius S. Involvement of extracellular calcium in phoshatidylserine exposure during apoptosis. FEBS Lett 1996; 399: 277–282.
Flatman PW. The control of red cell magnesium. Magnesium Res 1988; 1: 5–11.
Sambrook JF. The involvement of calcium transport secretory proteins from the endoplasmic reticulum. Cell 1990; 61: 197–199.
Bellomo G, Perotti M, Taddei F, et al. Tumor necrosis factor induces apoptosis in mammary adenocarcinoma cells by an increase in intranuclear Ca2+ concentration and DANN fragmentation. Cancer Res 1992; 52: 1342–1346.
Ojcius DM, Zynchinsky A, Zheng LM, Young JDE. Ionophore-induced apoptosis: Role of DNA fragmentation and calcium fluxes. Exp Cell Res 1991; 197: 43–49.
Gottlieb RA. Cell acidification in apoptosis. Apoptosis 1996; 1: 40.
Reynolds JE, Li J, Craig RW, Eastman A. Bcl-2 and MCL-1 expression in Chinese hamster ovary cells inhibits intracellular acidification induced by staurosporine. Exp Cell Res 1996; 225: 430.
Meisenholder GW, Martin SJ, Green DR, Nordberg J, Bernard MB, Gottlieb RA. Events in apoptosis: acidifiaction is downstream of protease activation and bcl-2 protection. J Biol Chem 1996; 271: 16260.
He H, Lam HH, McCormick TS, Distelhorst CW. Maintenance of calcium homeostasis in the endoplasmic reticulum by bcl-2. J Cell Biol 1998; 138:19976; 1219–1228.
Martin SJ, Reutelingsperger CPM, McGahon AJ, et al. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of bcl-2 and abl. J Exp Med 1995; 182: 1545–1556.
Bowmen ID, Bowmen SM. Programmed Cell Death in Tumours and Tissues. London: Chapman and Hall, 1990.
Evans GI, Wyllie AH, Gilbert CS, et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell 1992; 69: 119–128.
Vairo G, Inmes KM, Adams JM. Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival. Oncogene 1996; 13: 1511–1519.
Borner C. Diminished cell proliferation associated with the death protective activity of bcl-2. J Biol Chem 1996; 271: 12695–12698.
Simpson NH, Singh RP, Emery AN, Al-Rubeai. Bcl-2 overexpression reduces the growth rate and prolongs G1 phase in continuous chemostat cultures of hybridoma cells. Biotechnol Bioeng 1999; 64: 174–186.
Shimizu S, Eguchi Y, Kosaka H, Kamiike W, Matsuda H, Tsujimoto Y. Prevention of hypoxia induced cell death by bcl-2 and bcl-x
L. Nature 1995; 374: 811–813.
Shimizu S, Eguchi Y, Kamiike W, et al. Retardation of chemical hypoxia-induced necrotic cell death by bcl-2 and ICE inhibitors possible involvement of common mediators in apoptotic and necrotic signal transduction: Oncogene 1996; 12: 2045–2050.
Hirsch T, Marchetti P, Susin SA, et al. The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death. Oncogene 1997; 15: 1573–1581.
Zamzami N, Brenner C, Marzo I, Susin SA, Kroemer G. Subcellular and submitochondrial mode of action of bcl-2 like oncoproteins. Oncogene 1998; 16: 2265–2282.
Kruman I, Guo Q, Mattson MP. Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells. J Neurosci Res 1998; 51: 293–308.
Yu SP, Yeh CH, Sensi SL, et al. Mediation of neuronal apoptosis by enhancement of outward potassium current. Science 1997; 278: 114.
D'mello SR, Galli C, Ciotti T, Calissano. Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of cell death by insulin-like growth factor I and cAMP. Proc Natl Acad Sci USA 1993; 90: 10989.
Marakhova II, Vereninov AA, Toropova FV, Vinogrdova TA. Na+, K+-ATPase pump in activated human lymphocytes: on the mechanisms of rapid and long-term increase in K+ influxes during the initiation of phytohemagglutinin-induced proliferation. Biochimica et Biophysica Acta 1998; 1368: 61–72.
Al-Rubeai M, Emery AN, Chalder S, Goldman MH. A flow cytometric study of hydrodynamic damage to mammalian cells. J Biotechnol 1993; 31: 161–177.
Al-Rubeai M, Singh RP, Goldman MH, Emery AN. Death mechanisms of animal cells in conditions of agitation. Biotechnol Bioeng 1995; 45: 463.
Que FG, Gores GJ, Larusso NF. 1. Development and initial application of an in vitro model of apoptosis in rodent cholangiocytes. Am J Phsiol 1997; 272: (Gastrointest Liver Physiol 35): G106-G115.