Journal of Mammary Gland Biology and Neoplasia

, Volume 5, Issue 3, pp 289–294

The Normal and Malignant Mammary Gland: A Fresh Look with ERβ Onboard

  • Margaret Warner
  • Shigehira Saji
  • Jan-Åke Gustafsson

DOI: 10.1023/A:1009598828267

Cite this article as:
Warner, M., Saji, S. & Gustafsson, J. J Mammary Gland Biol Neoplasia (2000) 5: 289. doi:10.1023/A:1009598828267


Estrogens are important for the development and function of the normal mammary gland as well as for development of mammary cancer. The frontline therapy for treatment of estrogen receptor (ERα)4 positive breast cancer is antiestrogens. A second estrogen receptor (ERβ) is also expressed in the breast but it has not been measured because it is not detected by the immunoassays used to detect ERα. In many cell systems ERβ has actions which are opposite to those of ERα and this finding has raised questions about the role of ERβ in the development and treatment of breast cancer.

estrogen receptorβmammary gland

Copyright information

© Plenum Publishing Corporation 2000

Authors and Affiliations

  • Margaret Warner
    • 1
  • Shigehira Saji
    • 2
  • Jan-Åke Gustafsson
    • 3
  1. 1.Department of BioscienceKarolinska Institute, NOVUMHuddingeSweden
  2. 2.Department of Medical NutritionKarolinska Institute, NOVUMHuddingeSweden
  3. 3.Department of BioscienceKarolinska Institute, NOVUMHuddingeSweden