Journal of Mammary Gland Biology and Neoplasia

, Volume 5, Issue 3, pp 289-294

First online:

The Normal and Malignant Mammary Gland: A Fresh Look with ERβ Onboard

  • Margaret WarnerAffiliated withDepartment of Bioscience, Karolinska Institute, NOVUM
  • , Shigehira SajiAffiliated withDepartment of Medical Nutrition, Karolinska Institute, NOVUM
  • , Jan-Åke GustafssonAffiliated withDepartment of Bioscience, Karolinska Institute, NOVUM

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Estrogens are important for the development and function of the normal mammary gland as well as for development of mammary cancer. The frontline therapy for treatment of estrogen receptor (ERα)4 positive breast cancer is antiestrogens. A second estrogen receptor (ERβ) is also expressed in the breast but it has not been measured because it is not detected by the immunoassays used to detect ERα. In many cell systems ERβ has actions which are opposite to those of ERα and this finding has raised questions about the role of ERβ in the development and treatment of breast cancer.

estrogen receptorβ mammary gland