Journal of Mammary Gland Biology and Neoplasia

, Volume 6, Issue 1, pp 37–52

Wnt Signaling and Mammary Tumorigenesis

Article

DOI: 10.1023/A:1009564431268

Cite this article as:
Smalley, M.J. & Dale, T.C. J Mammary Gland Biol Neoplasia (2001) 6: 37. doi:10.1023/A:1009564431268

Abstract

Wnt expression patterns during mammary development support a role for Wnts in breast development and in mammary epithelial responses to systemic hormones. The deregulation of Wnt signaling also plays a role in breast cancer. Activation of the Wnt signaling pathway is a major feature of several human neoplasias and appears to lead to the cytosolic stabilization of a transcriptional co-factor, β-catenin. This co-activator can then regulate transcription from a number of target genes including the cellular oncogenes cyclin D1 and c-myc. This review will summarize the current state of knowledge of Wnt signal transduction in a range of model systems and will then address the role of Wnts and Wnt signaling in mammary development and cancer.

APCβ-cateninfrizzledmammarytumorWnt

Copyright information

© Plenum Publishing Corporation 2001

Authors and Affiliations

  1. 1.Developmental Biology Team, CRC Centre for Cell and Molecular BiologyInstitute of Cancer Research, Chester Beatty LaboratoriesLondonUnited Kingdom