Angiogenesis

, Volume 3, Issue 2, pp 117–123

A ncovel angiogenic factor derived from Aloe vera gel: β-sitosterol, a plant sterol

Authors

  • Eun-Joung Moon
    • Department of Molecular BiologyPusan National University
  • You Mie Lee
    • Department of Molecular BiologyPusan National University
  • Ok-Hee Lee
    • Department of Molecular BiologyPusan National University
  • Myoung-Jin Lee
    • Department of Molecular BiologyPusan National University
  • Seung-Ki Lee
    • College of PharmacySeoul National University
  • Myung-Hee Chung
    • College of MedicineSeoul National University
  • Young-In Park
    • College of Natural ResourcesKorea University
  • Chung-Ki Sung
    • College of PharmacyChonnam National University
  • Jae-Soo Choi
    • Department of Food and Life SciencePukyong National University
  • Kyu-Won Kim
    • Department of Molecular BiologyPusan National University
Article

DOI: 10.1023/A:1009058232389

Cite this article as:
Moon, E., Lee, Y.M., Lee, O. et al. Angiogenesis (1999) 3: 117. doi:10.1023/A:1009058232389

Abstract

Aloe vera gel has a beneficial effect on wound healing. Because angiogenesis is an essential process in wound healing, we hypothesized that Aloe vera gel might contain potent angiogenic compounds. Here we demonstrate that Aloe vera gel and its extracts are angiogenic on the chorioallantoic membrane (CAM) of chick embryo. Out of the three compounds purified from the final fraction of Aloe vera gel, β-sitosterol showed a potent angiogenic activity in the CAM assay. In the presence of heparin, β-sitosterol stimulated neovascularization in the mouse Matrigel plug assay and the motility of human umbilical vein endothelial cells in an in vitro wound migration assay. Thus β-sitosterol is a novel plant-derived angiogenic factor which may have potential pharmaceutical applications for the management of chronic wounds.

Aloe veraangiogenesisβ-sitosterolin vivo Matrigel plug assaymigration

Copyright information

© Kluwer Academic Publishers 1999