Transgenic Research

, Volume 9, Issue 2, pp 145–154

Role of the melanocortin-4 receptor in metabolic rate and food intake in mice

Authors

  • Airu S. Chen
    • Department of Metabolic Disorders, Merck Research Laboratories
  • Joseph M. Metzger
    • Department of Animal Pharmacology, Merck Research Laboratories
  • Myrna E. Trumbauer
    • Department of Metabolic Disorders, Merck Research Laboratories
  • Xiao-ming Guan
    • Department of Metabolic Disorders, Merck Research Laboratories
  • Hong Yu
    • Department of Metabolic Disorders, Merck Research Laboratories
  • Easter G. Frazier
    • Department of Metabolic Disorders, Merck Research Laboratories
  • Donald J. Marsh
    • Department of Metabolic Disorders, Merck Research Laboratories
  • Michael J. Forrest
    • Department of Animal Pharmacology, Merck Research Laboratories
  • Shobhna Gopal-Truter
    • Department of Comparative MedicineMerck Research Laboratories
  • Jill Fisher
    • Department of Comparative MedicineMerck Research Laboratories
  • Ramon E. Camacho
    • Department of Animal Pharmacology, Merck Research Laboratories
  • Alison M. Strack
    • Department of Animal Pharmacology, Merck Research Laboratories
  • Theodore N. Mellin
    • Department of Animal Pharmacology, Merck Research Laboratories
  • D. Euan MacIntyre
    • Department of Animal Pharmacology, Merck Research Laboratories
  • Howard Y. Chen
    • Department of Animal Pharmacology, Merck Research Laboratories
  • Lex H.T. Van der Ploeg
    • Department of Metabolic Disorders, Merck Research Laboratories
Article

DOI: 10.1023/A:1008983615045

Cite this article as:
Chen, A.S., Metzger, J.M., Trumbauer, M.E. et al. Transgenic Res (2000) 9: 145. doi:10.1023/A:1008983615045

Abstract

We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice. Intraperitoneal administration of the non-selective MC-R agonist melanotan II (MT-II; a cyclic heptapeptide) increases metabolic rate in wildtype mice, while MC-4R knockout mice are insensitive to the effects of MT-II on metabolic rate. MC-4R knockout mice are also insensitive to the effects of MT-II on reducing food intake. We conclude that MC-4R can mediate control of both metabolic rate and food intake in mice. We infer that a role for MC-3R in mediating the acute effects of MT-II on basal metabolic rate and food intake in wildtype mice seems limited.

food intakemelanocortin-4 receptormetabolic rateMT-II

Copyright information

© Kluwer Academic Publishers 2000