Cancer Causes & Control

, Volume 11, Issue 2, pp 137–144

A pooled analysis of thyroid cancer studies. V. Anthropometric factors


  • Luigino Dal Maso
    • Centro di Riferimento Oncologico
  • Carlo La Vecchia
    • Istituto di Ricerche Farmacologiche “Mario Negri”
    • Istituto di Statistica Medica e BiometriaUniversità degli Studi di Milano
  • Silvia Franceschi
    • Centro di Riferimento Oncologico
  • Susan Preston-Martin
    • Department of Preventive MedicineUniversity of Southern California
  • Elaine Ron
    • Division of Cancer Epidemiology and GeneticsNational Cancer Institute
  • Fabio Levi
    • Registre Vaudois des Tumeurs
  • Wendy Mack
    • Department of Preventive MedicineUniversity of Southern California
  • Steven D. Mark
    • Division of Cancer Epidemiology and GeneticsNational Cancer Institute
  • Anne McTiernan
    • Fred Hutchinson Cancer Research Center
  • Laurence Kolonel
    • Cancer Research Center of HawaiiUniversity of Hawaii at Manoa
  • Kiyohiko Mabuchi
    • Radiation Effects Research Foundation
  • Fan Jin
    • Shanghai Cancer Institute
  • Gun Wingren
    • Division of Occupational and Environmental Medicine, Faculty of Health SciencesLinköping University
  • Maria Rosaria Galanti
    • Department of Cancer EpidemiologyUniversity Hospital
  • Arne Hallquist
    • Department of OncologyKarolinska Institute and Stockholms Sjukhem
  • Eystein Glattre
    • Cancer Registry of Norway, Montebello
  • Eiliv Lund
    • Institute of Community MedicineUniversity of TromsØ
  • Dimitrios Linos
    • Institute of Preventive Medicine
  • Eva Negri
    • Istituto di Ricerche Farmacologiche “Mario Negri”

DOI: 10.1023/A:1008938520101

Cite this article as:
Maso, L.D., Vecchia, C.L., Franceschi, S. et al. Cancer Causes Control (2000) 11: 137. doi:10.1023/A:1008938520101


Objective: To assess the relation between anthropometric factors and thyroid cancer risk in a pooled analysis of individual data from 12 case–control studies conducted in the US, Japan, China and Europe.

Methods: 2056 female and 417 male cases, 3358 female and 965 male controls were considered. Odds ratios (OR) were derived from logistic regression, conditioning on age, A-bomb exposure (Japan) and study, and adjusting for radiotherapy.

Results: Compared to the lowest tertile of height, the pooled OR was 1.2 for females for the highest one, and 1.5 for males, and trends in risk were significant. With reference to weight at diagnosis, the OR for females was 1.2 for the highest tertile, and the trend in risk was significant, whereas no association was observed in males. Body mass index (BMI) at diagnosis was directly related to thyroid cancer risk in females (OR = 1.2 for the highest tertile), but not in males. No consistent pattern of risk emerged with BMI during the late teens. Most of the associations were observed both for papillary and follicular cancers, and in all age groups. However, significant heterogeneity was observed across studies.

Conclusions: Height and weight at diagnosis are moderately related to thyroid cancer risk.

body mass indexcase–control studiesheightriskthyroid cancerweight

Copyright information

© Kluwer Academic Publishers 2000