Evaluation of a measurement strategy for Parkinson's disease: Assessing patient health-related quality of life
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This study evaluated the feasibility and psychometric properties of self-completed and telephone interview versions of a patient health-related quality-of-life (HQL) questionnaire for Parkinson's disease that included the SF-36 Health Survey (SF-36), the Parkinson's Disease Questionnaire (PDQ-39), and the Medical Outcomes Study Sexual Function Survey. Parkinson's disease patients (n = 150) completed the questionnaire twice: once at the study site and once over the telephone in a randomized order. Ninety-four percent of enrolled patients completed the first HQL assessment and 88% completed both assessments. Cronbach's α exceeded 0.70 for all scales except for the self-completed PDQ-39 Social Support subscale (0.57) and the telephone interview PDQ-39 Social Support (0.60) and Cognitions (0.67) subscales and the SF-36 General Health (0.60) and Social Function (0.61) subscales. There were no statistically significant differences in mean HQL scale scores across the two modes of administration. Mean scores for 3 of the PDQ-39 subscales and the Summary Index were significantly poorer (p < 0.05) for patients at later clinical stages. Similarly, patients with dyskinesias reported significantly poorer scores for 4 of the PDQ-39 subscales and the Summary Index and patients with self-reported comorbidities reported poorer SF-36 Physical Function and General Health subscale scores than patients without dyskinesias and comorbidities, respectively. This study suggests that the self-completed and telephone interview versions of the patient HQL questionnaire are feasible and valid for future clinical trial applications.
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- Evaluation of a measurement strategy for Parkinson's disease: Assessing patient health-related quality of life
Quality of Life Research
Volume 9, Issue 1 , pp 87-100
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers
- Additional Links
- Health status
- Mode of administration
- Parkinson's disease
- Quality of life
- Industry Sectors
- Author Affiliations
- 1. Covance Health Economics and Outcomes Services Inc., Washington, DC
- 2. Astra Pharmaceuticals, L.P., Wayne, PA
- 3. Clinical Neuroscience Center, West Bloomfield, MI
- 4. Jefferson Medical College, Philadelphia, PA
- 5. Clinical Pharmaceutical Trials, Inc., Tulsa, OK