Journal of Materials Science: Materials in Medicine

, Volume 11, Issue 12, pp 811–815

Tissue reaction against a self-setting calcium phosphate cement set in bone or outside the organism

  • P. Frayssinet
  • M. Roudier
  • A. Lerch
  • J. L. Ceolin
  • E. Depre`s
  • N. Rouquet
Article

DOI: 10.1023/A:1008909714090

Cite this article as:
Frayssinet, P., Roudier, M., Lerch, A. et al. Journal of Materials Science: Materials in Medicine (2000) 11: 811. doi:10.1023/A:1008909714090

Abstract

Calcium phosphate cements are able to set in situ when injected into bone tissue. We evaluated the tissue reaction occurring when a DCPD-based calcium phosphate cement was either set within the bone or implanted when already set. The samples were implanted in rabbit condyles and examined histologically after 8 and 16 weeks. The relative bone surface, the fibrous capsule around the implants and the implant section surface were measured. Solid material seemed to be better tolerated than paste implants. More bone was found at the solid implant contact whatever the implantation time and the solid material degraded much less rapidly. In conclusion, the physico-chemical modification of the biological environment occurring during setting increases the foreign body reaction against the material.

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • P. Frayssinet
    • 1
    • 2
  • M. Roudier
    • 3
  • A. Lerch
    • 1
  • J. L. Ceolin
    • 4
  • E. Depre`s
    • 5
  • N. Rouquet
    • 1
  1. 1.Depuy-BiolandToulouseFrance
  2. 2.Laboratoire du Tissu Osseux et des Pathologies Oste´oarticulairesUniversite´ Paul SabatierToulouseFrance
  3. 3.Service d’Anatomie PathologiquePointe a` Pitre cedexFrance
  4. 4.Service de Chirurgie Pe´diatriquePointe a` Pitre cedexFrance
  5. 5.Domaine de I’INRAPrise d’eauFrance