Cancer Causes & Control

, Volume 9, Issue 4, pp 455–462

Screening endoscopy and risk of colorectal cancer in United States men

  • Charles S. Fuchs
  • Edward L. Giovannucci
  • Graham A. Colditz
  • Anne M. Kavanagh
Article

DOI: 10.1023/A:1008884021049

Cite this article as:
Fuchs, C.S., Giovannucci, E.L., Colditz, G.A. et al. Cancer Causes Control (1998) 9: 455. doi:10.1023/A:1008884021049

Abstract

Objectives: The purpose of this study was to describe the effect of screening endoscopy (sigmoidoscopy or colonoscopy) on colorectal cancer incidence and mortality. Methods: We used data from a prospective cohort study of 24,744 men aged 40 to 75 years in 1986, free from cancer and colon polyps, followed until 1994. The outcomes are diagnosis of colorectal cancer and death from colorectal cancer. Results: Screening endoscopy in 1986-87 was associated with a lower risk of all colorectal cancer (multivariate relative risk [RR]=0.58, 95 percent confidence interval [CI]=0.36-0.96); cancer in the distal colon or rectum (multivariate RR=0.40, CI=0.19-0.84); Dukes stage A&B (multivariate RR=0.66, CI=0.35-1.25); and Dukes stage C&D (multivariate RR=0.50, CI=0.20-1.26) colorectal cancer; and death from colorectal cancer (multivariate RR=0.56, CI=0.20-1.60), after adjusting for age and a wide range of colon cancer risk factors. Screening endoscopy in 1988-87 appeared to provide strong protection against distal stage C&D cancers (age-adjusted RR=0.16, CI=0.02-1.23) but no protection against proximal stage C&D cancers (age-adjusted RR=0.96, CI=0.32-2.91). Conclusions: This study provides strong evidence for a protective effect of screening sigmoidoscopy on colorectal cancer incidence and mortality and supports recommendations for screening sigmoidoscopy as an approach to colon cancer prevention.

Colorectal cancermenscreening endoscopyUnited States

Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Charles S. Fuchs
    • 1
  • Edward L. Giovannucci
    • 1
    • 2
  • Graham A. Colditz
    • 1
    • 2
  • Anne M. Kavanagh
    • 3
  1. 1.Channing Laboratory, Department of MedicineBrigham and Women's Hospital and Harvard Medical SchoolBoston(USA)
  2. 2.Harvard School of Public HealthBoston
  3. 3.Anti-Cancer Council of VictoriaAustralia