Cancer Causes & Control

, Volume 10, Issue 1, pp 35–42

Leukemias and lymphomas: time trends in the UK, 1984–93

  • Richard J.Q. McNally
  • Eve Roman
  • Ray A. Cartwright
Article

DOI: 10.1023/A:1008859730818

Cite this article as:
McNally, R.J., Roman, E. & Cartwright, R.A. Cancer Causes Control (1999) 10: 35. doi:10.1023/A:1008859730818

Abstract

Objective: To investigate recent time trends of some selected and common neoplasms of the blood and lymphatic tissues.

Methods: A specialist population-based register of hematological and related neoplasms was set up in parts of the UK in 1984. Secular changes over the first 10 years were investigated using log-linear Poisson modeling. The results are presented in tabular and graphical form.

Results: The analyses of 26,899 cases revealed a decline in incidence of acute myeloid leukaemia (AML), the myeloproliferative disorders (MPD) including chronic myeloid leukaemia (CML) and, in males only, Hodgkin's disease (HD). No secular trends for acute lymphoblastic leukaemia (ALL) were observed at any age. A marked increase in incidence in non-Hodgkin's disease (NHL) and the pre- leukemia group of myeloid dysplasias (MDS) was found.

Conclusions: The rise in MDS and decline in AML and related conditions are most likely to reflect diagnostic changes. Changes in NHL may reflect, in part, a similar phenomena, but an underlying upward trend cannot be excluded. The decline in HD is in one gender only and the significance of this remains to be investigated.

epidemiologyHodgkin's diseaseleukaemiamyelodysplasianon-Hodgkin's lymphomatime trends

Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Richard J.Q. McNally
    • 1
  • Eve Roman
    • 2
  • Ray A. Cartwright
    • 2
  1. 1.Leukaemia Research Fund Centre for Clinical EpidemiologyUniversity of LeedsLeedsUK
  2. 2.Leukaemia Research Fund Centre for Clinical EpidemiologyUniversity of LeedsLeedsUK