Journal of Computational Neuroscience

, Volume 4, Issue 2, pp 141–150

Simulation of Gamma Rhythms in Networks of Interneurons and Pyramidal Cells

  • Roger D. Traub
  • John G.R. Jefferys
  • Miles A. Whittington

DOI: 10.1023/A:1008839312043

Cite this article as:
Traub, R.D., Jefferys, J.G. & Whittington, M.A. J Comput Neurosci (1997) 4: 141. doi:10.1023/A:1008839312043


Networks of hippocampal interneurons, with pyramidal neuronspharmacologically disconnected, can generate gamma-frequency(20 Hz and above) oscillations. Experiments and models have shownhow the network frequency depends on excitation of the interneurons,and on the parameters of GABA{\rm A}-mediated IPSCs betweenthe interneurons (conductance and time course). Herewe use network simulations to investigate how pyramidal cells, connected tothe interneurons and to each other throughAMPA-type and/or NMDA-type glutamatereceptors, might modify the interneuron network oscillation. With orwithout AMPA-receptor mediated excitation of the interneurons, the pyramidal cells and interneurons fired in phaseduring the gamma oscillation. Synaptic excitation of the interneuronsby pyramidal cellscaused them to fire spike doublets or short bursts at gammafrequencies, thereby slowing the population rhythm.Rhythmic synchronized IPSPs allowed the pyramidal cells toencode their mean excitation by their phase of firing relativeto the population waves.Recurrent excitation between the pyramidal cells couldmodify the phase of firing relative to the population waves.Our model suggests that pools of synaptically interconnectedinhibitory cells are sufficient to produce gamma frequency rhythms,but the network behavior can be modified by participation ofpyramidal cells.

neuronal network40 Hzhippocampal EEG

Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Roger D. Traub
    • 1
    • 2
  • John G.R. Jefferys
    • 3
  • Miles A. Whittington
    • 4
  1. 1.IBM Research DivisionT.J. Watson Research CenterYorktown HeightsUSA
  2. 2.Department of NeurologyColumbia UniversityNew YorkUSA; E-mail
  3. 3.Department of PhysiologyThe Medical School, University of BirminghamBirminghamU.K.
  4. 4.Department of Physiology and BiophysicsSt. Mary‘s Hospital Medical School, Imperial CollegeLondonU.K.