Serum organochlorine pesticides and PCBs and breast cancer risk: results from a prospective analysis (USA)
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Objective: To prospectively evaluate relationships of organochlorine pesticides and polychlorinated biphenyls (PCBs) with breast cancer, we conducted a case-control study nested in a cohort using the Columbia, Missouri Breast Cancer Serum Bank.
Methods: Women donated blood in 1977–87, and during up to 9.5 years follow-up, 105 donors who met the inclusion criteria for the current study were diagnosed with breast cancer. For each case, two controls matched on age and date of blood collection were selected. Five DDT [2,2-bis(p-chlorophenyl)-1,1,1- trichloroethane] analogs, 13 other organochlorine pesticides, and 27 PCBs were measured in serum.
Results: Women in the upper three quartiles of hexachlorobenzene were at twice the risk of breast cancer compared to those in the lowest quartile. However, there was no evidence for a dose-response relationship, and the association was limited to women whose blood was collected close to the time of diagnosis. Women with higher serum levels of other organochlorine pesticides and PCBs showed no increased risk of breast cancer overall, although positive associations were suggested for PCB-118 and PCB-138 when blood was collected close to the time of diagnosis.
Conclusions: Results of this study do not support a role for organochlorine pesticides and PCBs in breast cancer etiology.
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- Serum organochlorine pesticides and PCBs and breast cancer risk: results from a prospective analysis (USA)
Cancer Causes & Control
Volume 10, Issue 1 , pp 1-11
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers
- Additional Links
- breast neoplasms
- organochlorine pesticides
- polychlorinated biphenyls
- Industry Sectors
- Author Affiliations
- 1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza North, Room 443, 6130 Executive Boulevard, Bethesda, MD, 20892–7374, USA
- 2. Division of Environmental Health Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
- 3. Ellis Fischel Cancer Center, Columbia, MO, USA
- 4. Growdon Distinguished Professor of Surgery Emeritus, University of Missouri Health Sciences Center, Columbia, MO, USA
- 5. Information Management Services, Inc., Silver Spring, MD, USA
- 6. Division of Clinical Sciences, National Cancer Institute, Bethesda, MD, USA