, Volume 9, Issue 4, pp 417-424

Serum concentrations of organochlorine compounds and endometrial cancer risk (United States)

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Objectives: Endogenous and exogenous estrogens are important in the development of endometrial cancer. Several organochlorine compounds, such as o,p′-DDT, have estrogenic properties. The objective of this case-control analysis was to examine serum concentrations of organochlorine compounds and risk of endometrial cancer.

Methods: Analyses were based on a sample of 90 endometrial cancer cases and 90 individually matched community controls from a multicenter case-control study in five geographic regions of the United States. Information on potential confounders, including menstrual and reproductive factors, cigarette smoking, diet, and weight, was obtained by interview.

Results: The adjusted relative risk of endometrial cancer in the highest quartile of exposure compared with women in the lowest quartile was 0.7 (95 percent confidence interval [CI] = 0.2-2.0) for p,p′-DDE, and 0.9 for total polychlorinated biphenyls (PCBs) (CI = 0.4-2.5).

Conclusions: These findings do not support the hypothesis that organochlorine compounds are linked to the development of endometrial cancer.