Cancer Causes & Control

, Volume 9, Issue 3, pp 277–283

Multiple Myeloma and Work in Agriculture: Results of a Case-Control Study in Forlì, Italy

  • Oriana Nanni
  • Fabio Falcini
  • Eva Buiatti
  • Lauro Bucchi
  • Monica Naldoni
  • Patrizia Serra
  • Emanuela Scarpi
  • Luca Saragoni
  • Dino Amadori
Article

DOI: 10.1023/A:1008821119851

Cite this article as:
Nanni, O., Falcini, F., Buiatti, E. et al. Cancer Causes Control (1998) 9: 277. doi:10.1023/A:1008821119851

Abstract

Objectives: To evaluate the relation between the exposure to specific pesticides in agricultural work and the risk of multiple myeloma (MM).

Methods: A case-control study was conducted in the province of Forlì, Italy. Forty-six cases of MM (20 females, 26 males; mean age 64 years, range 40 to 74) identified through the Romagna Cancer Registry in the years 1987-90, and 230 age- and gender-matched controls from the general population were interviewed in-person using a structured questionnaire focused on exposure to pesticides and other occupational and nonoccupational variables.

Results: Among nonoccupational factors, the education level and the altitude of the place of residence were related inversely to MM risk. First-degree familiarity for hematolymphopoietic neoplasias and previous herpes zoster diagnosis were associated positively with the disease. A nonsignificant increase in MM risk was observed among workers in agriculture as a whole (odds ratio [OR] = 1.31, 95 percent confidence interval [CI] = 0.62-2.74). An increased risk was associated specifically with the cultivation of apples and pears (OR = 1.75, CI = 1.05-2.91). As regards pesticide exposure, only the chlorinated insecticides were related to an increase in the risk of MM.

Conclusions: This study suggests that agricultural work and exposure to pesticides have a role in the etiology of MM. Cancer Causes and Control 1998, 9, 277-283

AgriculturealtitudeItalymultiple myelomapesticides

Copyright information

© Lippincott-Raven Publishers 1998

Authors and Affiliations

  • Oriana Nanni
    • 1
  • Fabio Falcini
    • 2
  • Eva Buiatti
    • 3
  • Lauro Bucchi
    • 4
  • Monica Naldoni
  • Patrizia Serra
    • 5
  • Emanuela Scarpi
    • 5
  • Luca Saragoni
    • 6
  • Dino Amadori
    • 2
  1. 1.Istituto Oncologico RomagnoloForlìItaly
  2. 2.Medical Oncology DepartmentLuigi Pierantoni HospitalForlìItaly
  3. 3.Epidemiology UnitCenter for Study and Prevention of CancerFlorenceItaly
  4. 4.Romagna Cancer RegistryForlìItaly
  5. 5.Istituto Oncologico RomagnoloForlìItaly
  6. 6.Pathology DepartmentLuigi Pierantoni HospitalForlìItaly